Emotional Communication Disorders in Cerebellar Disease
Ключавыя словы
Рэферат
Апісанне
The specific aims of this proposal will investigate the hypothesis that cerebellar damage is associated with emotional communication deficits.
- Determine whether posterior cerebellar damage results in deficits in the production or comprehension of emotional facial expressions and/or vocal prosodic expressions
- Determine whether posterior cerebellar damage results in alterations in intensity of reaction to emotionally evocative pictures or emotionally evocative words
- Investigate the relationship between performance on tests of emotional communication and left versus right cerebellar atrophy with magnetic resonance imaging imaging (MRI) using voxel based morphometry (VBM) analysis
All subjects (cerebellar and control) will be given the following testing in a single session of lasting 3 to 3 and a half hours. Included will be tests to assess reading ability, naming ability, several tests of memory, a test of ability to discriminate between faces, tests of mental flexibility, and standardized questionnaires for depression, anxiety and emotional empathy. The tests include:
1. Wechsler Test of Adult Reading
2. Montreal Cognitive Assessment
3. Beck Depression Inventory - 2
4. Wisconsin Card Sorting test
5. Toronto Alexithymia Scale
6. Multi-Dimensional Emotional Empathy Scale
All subjects will also be given tests assessing emotional communication ability. Tests of recognition and expression of emotional tones of voice and facial expression will be performed. Expression of facial expressions and tones of voice will be video recorded so that blinded raters can compare the accuracy and intensity of facial expressions and tones of voice between the participants. Training for the raters will include familiarization with the descriptions of features for each emotion with respect to changes in pitch, loudness, and rate for prosody and changes in facial features for facial expression. Both intra- and inter-judge reliability will be calculated for these blinded judges. To supplement this perceptual analysis, the participant's responses will be recorded using VisiPitch IV software, a clinical instrument that performs sound analyses and calculates the variation in the range of fundamental frequency (i.e., pitch variation) across each sentence. The ability to manipulate pitch to produce varying prosodic contours is the most salient acoustical feature of affective prosody.
We will also assess intensity ratings and descriptions of emotional pictures and words using materials that have established rating norms. Participants will be shown a series of pictures and asked to rate the emotional intensity of the picture. They will also be asked to give a brief description of the picture. They will then be given a list of words, one at a time, and asked to rate the emotional intensity of these words.
Some of the cerebellar participants will also be asked to participate in a magnetic resonance imaging (MRI) scan of the brain if the testing listed above shows deficits in understanding or producing emotional facial expressions or tones of voice and if there are no reasons that would prevent them from being able to enter a scanner (determined by a standard MRI screen form). Healthy control participants may also be asked to participate in a magnetic resonance imaging (MRI) scan of the brain and if there are no reasons that would prevent them from being able to enter a scanner. The imaging data will be used to investigate if there is a relationship between our experimental subjects' performance on tests of emotional expression and left versus right cerebellar atrophy-injury in the cerebellar lobules with MRI imaging using a voxel based morphometry (VBM) approach. The same data from controls will be used for comparison. Neuroimaging data collection will be done using a Philips Achieva 3T scanner (Amsterdam, Netherlands) and a 32-channel SENSE head coil. Imaging collected will include anatomical T1-weighted imaging scans. Structural MP-RAGE T1-weighted scans will be acquired with 130-1.0 mm sagittal slices, FOV=240 mm (AP)-180 mm (FH), matrix= 256-192, TR= 9.90 ms, TE= 4.60 ms, Flip Angle= 8, voxel size= 1.0x 0.94x 0.94 mm. Structural data will be analyzed with FSL-VBM, an optimized VBM protocol carried out with FSL tools. First, structural images will be brain-extracted and grey matter-segmented before being registered to the MNI 152 standard space using non-linear registration The resulting images will be averaged and flipped along the x-axis to create a left-right symmetric, study-specific grey matter template. Second, all native grey matter images will be non-linearly registered to this study-specific template and "modulated" to correct for local expansion (or contraction) due to the non-linear component of the spatial transformation. The modulated grey matter images were then smoothed with an isotropic Gaussian kernel with a sigma of 6 mm. Finally, voxelwise GLM will be applied using permutation-based non-parametric testing, correcting for multiple comparisons across space.
Даты
Апошняя праверка: | 12/31/2016 |
Упершыню прадстаўлена: | 04/02/2014 |
Меркаваная колькасць заявак прадстаўлена: | 04/02/2014 |
Першае паведамленне: | 04/07/2014 |
Апошняе абнаўленне адпраўлена: | 01/29/2017 |
Апошняе абнаўленне апублікавана: | 01/30/2017 |
Фактычная дата пачатку даследавання: | 03/31/2014 |
Разліковая дата першаснага завяршэння: | 12/30/2016 |
Разліковая дата завяршэння даследавання: | 12/30/2016 |
Стан альбо хвароба
Ўмяшанне / лячэнне
Behavioral: Testing of emotional communication ability
Procedure: magnetic resonance imaging (MRI) of the brain
Фаза
Групы ўзбраенняў
Рука | Ўмяшанне / лячэнне |
---|---|
Cerebellar Ataxia subjects 40 individuals with either hereditary or sporadic ataxia will have testing of emotional communication ability and may have magnetic resonance imaging (MRI) of the brain. | |
Healthy Control subjects 40 age matched controls will have testing of emotional communication ability and may have magnetic resonance imaging (MRI) of the brain. |
Крытэрыі прыдатнасці
Узрост, які мае права на вучобу | 18 Years Каб 18 Years |
Пол, прыдатны для навучання | All |
Метад адбору проб | Non-Probability Sample |
Прымае здаровых валанцёраў | Так |
Крытэрыі | Inclusion Criteria: - Men and women over the age of 18 - Individuals with cerebellar ataxia Exclusion Criteria: - Neurological signs reflecting major pathology in extrapyramidal, brainstem, cortical and visual systems - Symptomatic cerebellar ataxia from alcohol, toxins, vitamin deficiency, and paraneoplastic cerebellar degeneration - Dementia - Current symptoms of depression or severe anxiety - Currently on any psychotropic medication other than anti-depressants or history of a psychosis - Severe impairments of hearing or vision - Reading level less than 10th grade and/or history of learning disability - Chronic medical and neurological diseases other than cerebellar (e.g., cardiac failure, renal disease, hepatic failure, stroke) - History of severe head trauma (e.g., coma for more than one hour) |
Вынік
Першасныя вынікі
1. Florida Affect Battery [baseline]
Меры другаснага выніку
1. Perceptual rating of emotional expression [baseline]
2. Intensity and valence ratings of emotionally evocative pictures and words [baseline]
3. Magnetic resonance imaging of the brain [approximately one week post baseline]