Flavonoid Supplementation and Endothelial Function
Ключавыя словы
Рэферат
Апісанне
We propose to use a supplement made by NutraMetrix (called OPC-3), consisting of oligomeric proanthocyanidins derived from grape seed, pine bark, bilberry, citrus and red wine extracts, to determine effects on endothelial function, lipoproteins and inflammation. The primary outcome measure will be endothelial function as assessed by digital response to hyperemia using peripheral arterial tonometry, measured both in the fasting state and after a single standardized high-fat meal, when transient dysfunction is expected to occur. Secondary outcome measures will be the lipid profile, hs-CRP, and Lp-PLA2. The recruitment population will be healthy volunteers. The design will be a randomized, placebo-controlled, double-blind, cross-over trial lasting 10 weeks.
Даты
| Апошняя праверка: | 02/28/2007 |
| Упершыню прадстаўлена: | 05/25/2006 |
| Меркаваная колькасць заявак прадстаўлена: | 05/25/2006 |
| Першае паведамленне: | 05/28/2006 |
| Апошняе абнаўленне адпраўлена: | 03/13/2007 |
| Апошняе абнаўленне апублікавана: | 03/14/2007 |
| Фактычная дата пачатку даследавання: | 04/30/2006 |
| Разліковая дата завяршэння даследавання: | 11/30/2006 |
Стан альбо хвароба
Ўмяшанне / лячэнне
Drug: Isotonix OPC-3 (flavonoid supplement)
Фаза
Крытэрыі прыдатнасці
| Узрост, які мае права на вучобу | 18 Years Каб 18 Years |
| Пол, прыдатны для навучання | All |
| Прымае здаровых валанцёраў | Так |
| Крытэрыі | Inclusion Criteria: - 18 yrs of age or older - no pregnant potential Exclusion Criteria: - History of coronary artery disease - History of cerebrovascular disease - History of heart failure - Diabetes - Renal impairment - Uncontrolled hypertension - Untreated or clinically evident thyroid disease - Currently taking medications or supplements with known or potential lipid-altering effects including: phytosterols, statins, cholestin, niacin, fibrates, psyllium fiber, bile acid sequestrants, diabetic medications, and weight control medications such as orlistat - Pregnancy or breastfeeding - Tobacco use - Participants will be excluded with a history of smoking anytime in the past 6 months. - Inappropriate for participation in a study, if in the opinion of the investigator it is questionable whether the participant will be able to comply with all aspects of the protocol (e.g. inadequate cognitive skills, possible drug abuse or dependence, suspected psychiatric problems, etc.) |
Вынік
Першасныя вынікі
1. Change in endothelial function from baseline [undefined]
Меры другаснага выніку
1. CRP [undefined]
2. Lipid profile [undefined]
3. Lp-PLA2 [undefined]
