Genetic Study of Age Related Hearing Loss
Перакладаць артыкулы могуць толькі зарэгістраваныя карыстальнікі
Увайсці / Зарэгістравацца
Спасылка захоўваецца ў буферы абмену
СтатусЗавершаны
Спонсары
National Taiwan University Hospital
Калабаранты
National Science Council, Taiwan
КЛІНІЧНАЕ ВЫПРАБАВАННЕ: NCT01732289
BioSeek: nct01732289
Ключавыя словы
Рэферат
Age-related hearing loss, or presbyacusis, is one of the most common chronically handicapped conditions for the elderly. Many factors including genetics, diet, diseases, drugs, socioeconomic factors and environmental variables were considered to be related to the development of presbyacusis. Evidences have shown that genetic factors play an important role on presbyacusis. However, which genes or their genotypes are associated with presbycusis remain unknown.
The aim of this project was to evaluate the association between the genotype of candidate genes and presbyacusis by cross-section and case-control study. In the first stage, the investigators plan to select 700 healthy subjects older than 50 with symmetric, sensorineural hearing loss. The subjects will receive basic otologic examination, pure tone audiometry, questionnaire, and genotype analysis. Because gender and age would affect hearing loss significantly, The investigators will convert the hearing level of all subjects into a gender and age independent Z-score according to ISO 7029 standard. And, The investigators define subjects within higher 30 % of Z-score as the presbyacusis group, and subjects within lower 30% of Z-score as the control group. Finally, The investigators perform Chi square analysis to test the association between genotype of candidate genes or their combinations in both groups, and calculate the odds ratio for presbyacusis between different genotype of candidate genes. Further more, we will evaluate the effect of genotype of candidate genes, environment factors, and gene-environmental interaction on the severity of presbyacusis by multivariate logistic regression.
In the second stage, The investigators wish to know the pattern of genotype and hearing level in the high risk families, according to results from the first stage, by description and case-control study. The investigators will perform t-test to evaluate the difference of Z-score in both groups. Besides, The investigators try to evaluate the effects of genotypes, environment factors, and gene-environmental interaction on hearing level in high risk families by multivariate logistic regression.
Даты
Апошняя праверка: | 10/31/2012 |
Упершыню прадстаўлена: | 08/31/2008 |
Меркаваная колькасць заявак прадстаўлена: | 11/20/2012 |
Першае паведамленне: | 11/21/2012 |
Апошняе абнаўленне адпраўлена: | 11/20/2012 |
Апошняе абнаўленне апублікавана: | 11/21/2012 |
Фактычная дата пачатку даследавання: | 07/31/2008 |
Разліковая дата першаснага завяршэння: | 06/30/2009 |
Разліковая дата завяршэння даследавання: | 06/30/2009 |
Стан альбо хвароба
Age-related Hearing Loss
Presbycusis
Ўмяшанне / лячэнне
Genetic: A
Фаза
-
Групы ўзбраенняў
Рука | Ўмяшанне / лячэнне |
---|---|
Experimental: A | Genetic: A Draw blood for genetic screening |
Крытэрыі прыдатнасці
Узрост, які мае права на вучобу | 45 Months Каб 45 Months |
Пол, прыдатны для навучання | All |
Прымае здаровых валанцёраў | Так |
Крытэрыі | Inclusion Criteria: - subjects aged 45 or above, both male and female came to the hospital for health check up Exclusion Criteria: - known ontological disease age under 45 noise exposure history history of ototoxicity psychiatric diseases |
Вынік
Першасныя вынікі
1. which gene or Single nucleotide polymorphism is related to age related hearing loss [2008-2009]
Меры другаснага выніку
1. Which environmental factor(s) or systemic diseases are related to age related hearing loss [2008-2009]