Mediterranean Diet Treatment for NAFLD
Ключавыя словы
Рэферат
Апісанне
Non-alcoholic fatty liver disease (NAFLD) is a disease caused by abnormal lipid accumulation in the liver without alcohol intake or other organic causes. NAFLD covers a range of liver diseases ranging from simple oil infiltration to non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. The most important risk factor in the development of NAFLD is insulin resistance due to obesity. Insulin resistance increases hepatic steatosis and accumulation of hepatic fatty acids by increasing peripheral lipolysis and the entry of fatty acids into the liver. In parallel with the increased prevalence of childhood obesity, the occurrence of NAFLD is increasing among children. The risk that the NAFLD can turn into chronic liver disease increases the importance of the disease even more when children become adults Mediterranean Diet (MD) has gained popularity in scientific literature because it is one of the healthiest diets in the world.This diet is based on the high intake of extra virgin olive oil, vegetables, fruits, cereals, nuts and legumes; moderate intakes of fish and other meats, dairy products and red wine and low intakes of eggs and sweets. So, it provides a large amount of monounsaturated fatty acids, polyunsaturated fatty acids, vegetable proteins, fibre and antioxidants; and low amounts of sugar, cholesterol and saturated fats. MD is characterized as low-carbohydrate (40% of calories) and in contrast to low-fat diets, the MD includes fat as 40% of the diet. It offers a lot of choice in food selection, and well tolerated, and many people can adhere to it over the long term. There are a limited number of studies investigating the effectiveness of the MD in NAFLD treatment in different countries. However, there are no studies in the treatment of children with NAFLD in Turkey. The primary aims to this study is to evaluate the effects of a MD vs. low fat diet on changes in hepatic steatosis, aminotransferases, and anthropometric measurements among obese children with NAFLD in Turkey. The secondary aim to this study is to evaluate the effects of the both diets in insulin resistance.
Даты
| Апошняя праверка: | 04/30/2020 |
| Упершыню прадстаўлена: | 05/26/2020 |
| Меркаваная колькасць заявак прадстаўлена: | 05/29/2020 |
| Першае паведамленне: | 06/03/2020 |
| Апошняе абнаўленне адпраўлена: | 05/29/2020 |
| Апошняе абнаўленне апублікавана: | 06/03/2020 |
| Фактычная дата пачатку даследавання: | 12/31/2017 |
| Разліковая дата першаснага завяршэння: | 11/30/2019 |
| Разліковая дата завяршэння даследавання: | 02/29/2020 |
Стан альбо хвароба
Ўмяшанне / лячэнне
Behavioral: Mediterranean Diet
Behavioral: Low Fat Diet
Фаза
Групы ўзбраенняў
| Рука | Ўмяшанне / лячэнне |
|---|---|
| Active Comparator: Mediterranean Diet The MD diet is rich in plant based foods including vegetables, whole cereal and fruit with the main added fat being extra virgin olive oil. In addition, the diet emphasises, while consumption of legumes, nuts and fish is high, consumption of red meat and home-made desserts is low, and consumption of fermented milk and poultry is moderate. The MD diet had a target macronutrient composition of 35-40% fat (with <10% of energy as saturated fat), 40-44% carbohydrate and 20% protein. | Behavioral: Mediterranean Diet A list of foods high consumption of vegetables, fruits, non-refined cereals, legumes and potatoes, moderate consumption of fish and poultry and low consumption of full fat dairies, red meat and its products and homemade sweets. |
| Active Comparator: Low Fat Diet The Low Fat diet had a target macronutrient composition of 55% of energy from carbohydrate, 20-25% from fat (with <10% of energy as saturated fat) and 20-25% from protein. Nutrition education focused on choosing foods containing ≤3 grams of fat/serving, limiting added fats, and using low-fat meal preparation strategies. Parents were instructed to offer their children ample amounts of grains, vegetables, fruits, lean meats, low-fat dairy products and limit high-fat foods | Behavioral: Low Fat Diet These children are forbidden to eat high-fat foods such as fried foods, butter, cream cheese, while foods such as fruits, vegetables (starchy and non-starch), cereals, poultry, lean meat and low-fat dairy products are allowed. |
Крытэрыі прыдатнасці
| Узрост, які мае права на вучобу | 9 Years Каб 9 Years |
| Пол, прыдатны для навучання | All |
| Прымае здаровых валанцёраў | Так |
| Крытэрыі | Inclusion Criteria: - Diagnosis of NAFLD - Body mass index z-score >85th percentile Exclusion Criteria: - Secondary causes of NAFLD (eg. medication induced) - Use of weight loss medications - Diabetes Mellitus - Other causes of fatty liver disease (eg. Wilson disease, alpha-1 antitrypsin deficiency, auto-immune hepatitis, and viral hepatitis) |
Вынік
Першасныя вынікі
1. Non-alcoholic Fatty Liver Disease Ultrasonography Score [12 weeks]
Меры другаснага выніку
1. Evaluate the effects of the both diets in insulin resistance [12 weeks]
2. Evaluate the effects of the both diets in capillary blood glucose [12 weeks]
3. Evaluate the effects of the both diets in fasting insulin levels [12 weeks]
