Metabolomic and Proteomic Profiles of Amniotic Fluid Embolism
Ключавыя словы
Рэферат
Даты
Апошняя праверка: | 01/31/2020 |
Упершыню прадстаўлена: | 02/02/2020 |
Меркаваная колькасць заявак прадстаўлена: | 02/03/2020 |
Першае паведамленне: | 02/04/2020 |
Апошняе абнаўленне адпраўлена: | 02/03/2020 |
Апошняе абнаўленне апублікавана: | 02/04/2020 |
Фактычная дата пачатку даследавання: | 02/29/2020 |
Разліковая дата першаснага завяршэння: | 02/28/2021 |
Разліковая дата завяршэння даследавання: | 02/28/2021 |
Стан альбо хвароба
Ўмяшанне / лячэнне
Biological: Biological analysis
Фаза
Групы ўзбраенняў
Рука | Ўмяшанне / лячэнне |
---|---|
AFE (amniotic fluid embolism) Women for whom the diagnosis of amniotic fluid embolism was retained according to the UKOSS criteria. | |
Control 1 Women admitted for prophylactic elective cesarean section. | |
Control 2 Women with acute collapse in the peripartum period (with systolic blood pressure <80 mmHg twice and for> 5 minutes or acute peri-partum shock, for which the diagnosis of amniotic embolism has been ruled out). |
Крытэрыі прыдатнасці
Узрост, які мае права на вучобу | 18 Years Каб 18 Years |
Пол, прыдатны для навучання | Female |
Метад адбору проб | Non-Probability Sample |
Прымае здаровых валанцёраў | Так |
Крытэрыі | Inclusion Criteria: - Group AFE - adult women - presenting the diagnostic criteria for amniotic embolism according to the UKOSS initiative, - having no known notable medical history (class of the American Society of Anesthesiologists 1) - and whose samples were taken within the first 6 hours of collapse and were sent to the fetal-maternal biology laboratory of the Hospices Civils de Lyon (HCL). - Group Control 1 - term adult women - admitted for scheduled caesarean, term (> 38 weeks), without pathology or associated medical history (class of the American Society of Anesthesiologists 1), - biological sample planned before the cesarean section (search for irregular agglutinins). - Group Control 2: - term adult women (> 38 weeks) - presenting a collapse (systolic blood pressure <80 mmHg twice and for> 5 minutes) or acute peri-partum shock, for which the diagnosis of amniotic embolism is not retained, - no known notable medical history (class of the American Society of Anesthesiologists 1), - sampling taken within the first 6 hours of the shock or collapse. Exclusion Criteria: - Refusal to participate - birth as part of an intrauterine fetal death or a therapeutic termination of pregnancy - preeclampsia, eclampsia - Gestational Diabetes - any known endocrine pathology (diabetes, dysthyroidism, adrenal insufficiency, pituitary and hypothalamic diseases). - history of autoimmune disease - hemoglobin rate <7 g / dl at the time of sampling (Control group 1 and 2) - major protected (guardianship, curatorship) or placed under judicial protection |
Вынік
Першасныя вынікі
1. Metabolic phenotyping of amniotic fluid embolism [6 hours]
2. Proteomic analysis of amniotic fluid embolism [6 hours]