Study of the Pathogenesis of Rett Syndrome
Ключавыя словы
Рэферат
Апісанне
PROTOCOL OUTLINE: Patients receive a comprehensive clinical evaluation including an ophthalmologic exam; speech, communication, and developmental assessment; nutritional evaluation; neurologic exam; respiratory monitoring; and cytogenetic studies.
Selected patients with malnutrition are given night feedings of Pediasure with Fiber by nasogastric tube. Specific recommendations for feeding techniques and diet are made.
Selected patients with seizures or severe hyperventilation and progressive rigidity are nonrandomly assigned to dextromethorphan or topiramate therapy.
Oral dextromethorphan is maintained 6 months to 1 year; duration of therapy depends on response. Oral topiramate is given for 6 months to 1 year, and Aricept for 6 months to 1 year.
Concurrent anticonvulsants may require dose adjustments while on above protocols. Supportive care for constipation, scoliosis, and weight loss is allowed.
Даты
| Апошняя праверка: | 11/30/1998 |
| Упершыню прадстаўлена: | 02/23/2000 |
| Меркаваная колькасць заявак прадстаўлена: | 02/23/2000 |
| Першае паведамленне: | 02/24/2000 |
| Апошняе абнаўленне адпраўлена: | 06/22/2005 |
| Апошняе абнаўленне апублікавана: | 06/23/2005 |
| Фактычная дата пачатку даследавання: | 12/31/1994 |
Стан альбо хвароба
Ўмяшанне / лячэнне
Drug: dextromethorphan
Drug: topiramate
Drug: Donepezil
Фаза
Крытэрыі прыдатнасці
| Пол, прыдатны для навучання | All |
| Прымае здаровых валанцёраў | Так |
| Крытэрыі | PROTOCOL ENTRY CRITERIA: Rett syndrome Diagnosis confirmed on study |
