Increased FDG uptake in scrotal steatocystoma multiplex with calcification.

Steatocystoma multiplex is a rare, benign, sporadic or familial disorder. Steatocystoma multiplex with extensive calcification is extremely rare. A 57-year-old man presented fever and cough with expectoration for 3 weeks. Chest CT showed bilateral pleural effusion. FDG PET/CT showed diffuse FDG uptake of the bone marrow and multiple hypermetabolic calcified nodules in the scrotum with SUVmax of 7.6. Blood culture revealed septicemia. Skin biopsy of the scrotal nodules revealed steatocystoma multiplex with calcification. Histopathologically, there were rich multinucleated giant cells and lymphocytes in the cyst wall of the steatocystoma, which may contribute to the increased FDG uptake.