Murihexol, a linear acetogenin from Annona muricata.

Murihexol (1), a novel acetogenin, and three known ones, donhexocin (2), annonacin A and annonacin, have been isolated from the seeds of Annona muricata. Compound 1 is a C(35) acetogenin without any THF rings, with six hydroxyls in the long aliphatic chain. The hydroxyls of 1 and 2 are all located at C-4, C-10, C-15, C-16, C-19 and C-20, but their stereochemistries are different. The vicinal diol at C-15/C-16 in 1 is threo and C-19/C-20 has the erythro configuration; in 2 C-15/C-16 and C-19/C-20 all have the same threo configuration.