The cryoneurolysis device will be triggered using 3 cycles of 2-minute gas activation (active or sham) separated by 1-minute defrost periods.

For the sham probes, the nitrous oxide will be vented prior to reaching the probe shaft, resulting in a lack of perineural temperature change.

Rib Fractures

The cryoneurolysis device will be triggered using 3 cycles of 2-minute gas activation separated by 1-minute defrost periods for the target intercostal nerves.

Cryoneurolysis

Sham comparator

University California San Diego

Intercostal Cryoneurolysis Following Traumatic Rib Fractures

Pain score measured using the numeric rating scale for pain: 0=no pain and 10=worst imaginable pain

Pain score measured using the numeric rating scale for pain

Number of opioid tablets consumed previous 24 hours (oxycodone 5 mg)

Measured using the Brief Pain Inventory (BPI) which, in addition to pain intensity scales (of 0-10, 0=no pain and 10=worst imaginable) includes seven measures evaluating pain's interference with physical and emotional functioning, such as sleep, relations with others, and enjoyment of life (0-10 scale, 0=no interference and 10=worst imaginable interference). Subscales for both pain scores and the interference scores will be reported along with total scores and scores for each individual question.

Brian M. Ilfeld, MD, MS

Professor of Anesthesiology, In Residence

University of California, San Diego

Randomized, double-masked, sham-controlled, parallel-arm human subjects clinical trial

Cryoneurolysis probes are available for a console neurolysis device (PainBlocker, Epimed, Farmers Branch, Texas) that either (1) pass nitrous oxide to the tip inducing freezing temperatures; or, (2) vent the nitrous oxide at the base of the probe so that no gas reaches the probe tip, resulting in no temperature change. The latter is a sham procedure since without the temperature change, no ice ball forms and therefore the target nerve is not affected.

isopropyl alcohol/атрафія

Intercostal Cryoneurolysis Following Traumatic Rib Fractures

Самая поўная база дадзеных пра лекавыя травы, падтрыманая навукай