Patients with CVC managed by healthcare workers trained/retrained to GAVECELT recommendations.

Patients with CVC managed by healthcare workers trained/retrained to GAVECELT recommendations with the aid of port protector devices.

Central Line-associated Bloodstream Infection (CLABSI)

Physicians and nurses of RICU have been trained and retrained to GAVECELT "bundle" recommendations concerning the management of CVC. The bundle includes: hand hygiene and precautions for protection and safety, adequate insertion site, echo-guided placement of central venous line, use of clorexidine 2% for skin disinfection of insertion site chosen and subsequent continuous or discontinuous disinfection of exit site, use of suture-less devices, use of transparent semi-permeable dressing whenever applicable and immediate removal of catheter when no longer needed.
After the first training meeting, the use of Curos® Disinfecting Port Protector for needleless valves port-protector has been introduced.

Training and retraining to GAVECELT "bundle" recommendations plus port protector

Physicians and nurses of RICU have been trained and retrained to GAVECELT "bundle" recommendations concerning the management of CVC. The bundle includes: hand hygiene and precautions for protection and safety, adequate insertion site, echo-guided placement of central venous line, use of clorexidine 2% for skin disinfection of insertion site chosen and subsequent continuous or discontinuous disinfection of exit site, use of suture-less devices, use of transparent semi-permeable dressing whenever applicable and immediate removal of catheter when no longer needed.

Training and retraining to GAVECELT "bundle" recommendations

Port Protectors for Prevention of CLABSIs in Respiratory Semi-intensive Care Unit

Randomized Clinical Trial on the Role of Port Protectors for the Management of Venous Central Line Catheter in Respiratory Semi-intensive Care Unit.

Efficacy of educational interventions alone and combined with port protector as adjuvant tool on rate of CLABSIs.

Efficacy of educational interventions alone and combined with port protector as adjuvant tool on rate of CVC colonizations.

Efficacy of educational interventions alone and combined with port protector as adjuvant tool on rate of contaminated blood cultures.

Riccardo Inchingolo

Principal Investigator

Catholic University of the Sacred Heart

Patients have been randomized into two groups:
patients with CVC managed by healthcare workers trained/retrained to GAVECELT recommendations.
Patients with CVC managed by healthcare workers trained/retrained to GAVECELT recommendations with the aid of port protector devices.

normal thermal condition with core temperatures between 36.5°C and 37°C

mild hypothermia with core temperatures between 34.5°C and 35°C

mild hypothermia with core temperatures between 34.5°C and 35°C
sugammadex: sugammadex 4.0 mg/kg is administered in deep block state(1 - 2 PTCs) in different temperature state
Reversal effect of sugammadex in temperature state

H Group

normal thermal condition with core temperatures between 36.5°C and 37°C
sugammadex: sugammadex 4.0 mg/kg is administered in deep block state(1 - 2 PTCs) in different temperature state
Reversal effect of sugammadex in temperature state

C Group

Total

Sex: Female, Male

Region of Enrollment

The time from the administration of sugammadex to recovery of the TOF ratio to 0.9 in deep neuromuscular block (1-2 twitches post-tetanic count) induced by rocuronium during mild hypothermia with core temperatures between 34.5°C and 35°C, and compared with the normal thermal condition.

Reversal Time of Rocuronium

Incidence of Residual Neuromuscular Blockade

Post-operative Nausea and Vomiting

adverse effect of sugammadex(hypersensitivity, dry mouth, hypertension etc.)

Adverse Events

From the start of administration of sugammadex to recovery of the TOF ratio to 0.7 or 0.8 in both groups, mean arterial blood pressure at 1 min before reversal(pre-reversal), 1 min after reversal(post-reversal), recovery and 1 day after surgery (post-anesthetic visit).

Mean Arterial Blood Pressure

From the start of administration of sugammadex to recovery of the TOF ratio to 0.7 or 0.8 in both groups, Heart rate at 1 min before reversal(pre-reversal), 1 min after reversal(post-reversal), recovery and 1 day after surgery (post-anesthetic visit).

Heart Rate

Overall Study

Kyo Sang Kim, MD, PhD

Underdosing of Other General Anesthetics

sugammadex 4.0 mg/kg is administered in deep block state(1 - 2 PTCs) in different temperature state
Reversal effect of sugammadex in temperature state

sugammadex

Department of Anesthesiology and Pain Medicine, Hanyang University Hospital

Influence of Mild Hypothermia on Reversal of Rocuronium With Sugammadex

A Randomized, Parallel-group, Safety-assessor-blinded Phase IV Study to Estimate the Influence of Mild Hypothermia on Reversal of Rocuronium-induced Neuromuscular Block With Sugammadex

isopropyl alcohol/ліхаманка

Port Protectors for Prevention of CLABSIs in Respiratory Semi-intensive Care Unit

Influence of Mild Hypothermia on Reversal of Rocuronium With Sugammadex

Самая поўная база дадзеных пра лекавыя травы, падтрыманая навукай