A Supervised Nutritional Program in Pregnancies and NF-κB Expression in Placenta
Ключови думи
Резюме
Описание
Obesity during pregnancy is associated with exaggerated metabolic adaptation, endothelial dysfunction and an increased risk of adverse pregnancy outcomes, including preeclampsia, a major cause of maternal and fetal morbidity and mortality characterized by increased blood pressure, proteinuria and edema, which affects approximately 3% to 7% of all pregnant women. Other risk factors, besides obesity, that increase the likelihood of developing preeclampsia include chronic hypertension, and diabetes mellitus.
Reactive oxygen species (ROS) [superoxide anions (•O2-), hydrogen peroxide (H2O2) and hydroxyl radicals (•OH)],5 interact with proteins, nucleic acids and lipids and in a process called lipid peroxidation (LPO), can cause severe cell and tissue damage. There is current evidence that ROS are common activators of nuclear factor-kappa B (NF-κB), a factor that initiates a systemic inflammatory process by promoting the synthesis of cytokines, interleukin (IL)-6, IL-8, monocyte chemotactic protein-1 (MCP-1) and expression of intercellular adhesion molecule (ICAM-1).
To maintain balance of the oxidative state, the human body possesses intracellular antioxidant enzyme systems, including superoxide dismutase (SOD, glutathione peroxidase (GPx), and catalase (CAT), which is located mainly in peroxisomes and cytoplasm of the cell.
The epidemiology of preeclampsia, which is more common among poor women, had previously suggested that nutrients may be involved in the disorder, unfortunately, the nutritional data obtained from women with the syndrome has been poorly defined.
The objective of this paper was to provide an overview of the biological plausibility and potential mechanisms underlying associations among maternal nutrition, oxidative stress in placenta and the risk of preeclampsia.
Дати
Последна проверка: | 07/31/2012 |
Първо изпратено: | 08/14/2012 |
Очаквано записване подадено: | 08/15/2012 |
Първо публикувано: | 08/16/2012 |
Изпратена последна актуализация: | 08/15/2012 |
Последна актуализация публикувана: | 08/16/2012 |
Действителна начална дата на проучването: | 05/31/2009 |
Приблизителна дата на първично завършване: | 11/30/2010 |
Очаквана дата на завършване на проучването: | 05/31/2011 |
Състояние или заболяване
Интервенция / лечение
Behavioral: pregnancy diet
Фаза
Групи за ръце
Arm | Интервенция / лечение |
---|---|
Experimental: pregnancy diet Healthy Eating Index (HEI) in supervised pregnancies | Behavioral: pregnancy diet Dietetic treatment was calculated according to height, weeks of gestation and weight, considering an energy intake of 30 kcal/kg of expected weight, distributing the resulting energy according to the percentage of macronutrients' adequation (55-65% carbohydrates, 10-20% fat and the remainder as proteins).16 On each nutritional visit, 24 hour dietary recall was done and analyzed using NutriKcal®VO software in order to evaluate the Healthy Eating Index (HEI), which is commonly employed to assess pregnant women's dietary adequacy (on a scale from 0-100), through the consumption of 12 components of food groups described previously. An improvement in diet was considered when the initial HEI score improved more than one point during the next nutritional assessment. |
No Intervention: unsupervised pregnancy women attending the obstetrics unit who did not follow a supervised diet |
Критерии за допустимост
Възрасти, отговарящи на условията за проучване | 18 Years Да се 18 Years |
Полове, допустими за проучване | Female |
Приема здрави доброволци | Да |
Критерии | Inclusion Criteria: - Women in their first trimester of pregnancy Exclusion Criteria: - multiple pregnancies - prior history of chronic-metabolic diseases |
Резултат
Първични изходни мерки
1. Placental expression of NF-κB [two years]