Cloud-Based Mapping for Personalized Ablation
Ключови думи
Резюме
Описание
This project will focus on the development of a novel paradigm for electrophysiologic data analysis and interpretation using cloud-based computing resources and mobile technology. Currently, electrophysiologic data gathered during a procedure is analyzed by the operator using multiple separate desk-based computer systems in the electrophysiology laboratory. The investigators propose that advances in cloud-based computing resources and network connectivity should apply a mobile paradigm to apply to invasive electrophysiologic procedures.
This project will provide proof-of-concept that open-access software the investigators have developed and made available online could be used, via a mobile phone interface, to identify sites in the heart where therapy is effective. At no time will patient therapy be guided by this system. The investigators will pursue therapy using only clinical means. In parallel, a double-blinded team will analyze data in real time using our online software visualized on a smartphone. Only when the case is concluded will the data be unblinded, to determine if the mobile system was accurate in real time.
Thus, development and testing of the cloud-based computing system is designed only to establish feasibility of the paradigm, followed by improvement of computational modeling algorithms. The data that is collected will add to the investigators' existing unique catalogue of multimodal (structural, clinical, and electrophysiologic) data.
The importance of this novel paradigm is to move from analyzing large volumes of data in isolation to creating a mobile platform, and to allow scalability to increase access, such as to underdeveloped medical centers.
Дати
Последна проверка: | 09/30/2019 |
Първо изпратено: | 03/31/2019 |
Очаквано записване подадено: | 10/10/2019 |
Първо публикувано: | 10/14/2019 |
Изпратена последна актуализация: | 10/10/2019 |
Последна актуализация публикувана: | 10/14/2019 |
Действителна начална дата на проучването: | 07/02/2019 |
Приблизителна дата на първично завършване: | 04/14/2021 |
Очаквана дата на завършване на проучването: | 12/30/2021 |
Състояние или заболяване
Фаза
Критерии за допустимост
Възрасти, отговарящи на условията за проучване | 21 Years Да се 21 Years |
Полове, допустими за проучване | All |
Метод за вземане на проби | Non-Probability Sample |
Приема здрави доброволци | Да |
Критерии | Inclusion Criteria: - men and women of any ethnicity - aged 21-80 years - undergoing ablation of atrial fibrillation at Stanford University - failed or be intolerant of ≥ 1 anti-arrhythmic drug or not willing to accept antiarrhythmic drug therapy. Exclusion Criteria: - active coronary ischemia or decompensated heart failure - atrial or ventricular clot on trans-esophageal echocardiography - pregnancy (to minimize fluoroscopic exposure) - inability or unwillingness to provide informed consent - rheumatic valve disease (because it results in a unique AF phenotype) - thrombotic disease or venous filters - significantly reduced kidney function |
Резултат
Първични изходни мерки
1. Mapping Accuracy [During Procedure (Electrophysiology Study and Ablation)]
2. Termination of atrial fibrillation [During Procedure (Electrophysiology Study and Ablation)]