Normal Saline Vrs Balanced i.v. Fluids in Neurosurgery
Ключови думи
Резюме
Описание
Normal saline or 0.9% sodium chloride solution is the most commonly used intravenous fluid worldwide and its composition are 154 mmol Na+ and 154 mmol Cl- per litter with osmolality of 308 mOsmol/L. That composition is not "normal" because plasma contains potassium in range between 137-146 mmol/L, and chloride in range between 98-106 mmol/L, with plasma osmolality of 280-295 mOsmol/kg. Recently published data suggested detrimental effects of chloride rich fluids on renal blood flow and glomerular filtration rate, urine output and acute kidney injury. One alternative to saline solution is a buffered, balanced, crystalloid solution with an electrolyte composition similar to plasma and osmolality between 286-295 mOsmol/L. Someone could indicate that such balanced solutions are not suitable for neurosurgical patients because of a possible impact on the brain edema development.
Дати
Последна проверка: | 03/31/2019 |
Първо изпратено: | 02/02/2018 |
Очаквано записване подадено: | 02/07/2018 |
Първо публикувано: | 02/11/2018 |
Изпратена последна актуализация: | 04/15/2019 |
Последна актуализация публикувана: | 04/17/2019 |
Действителна начална дата на проучването: | 03/22/2017 |
Приблизителна дата на първично завършване: | 10/22/2019 |
Очаквана дата на завършване на проучването: | 02/22/2020 |
Състояние или заболяване
Интервенция / лечение
Other: Normal saline fluid group
Other: Balanced fluid group
Фаза
Групи за ръце
Arm | Интервенция / лечение |
---|---|
Normal saline fluid group The patients in this group will receive up to 2000 ml of normal saline during neurosurgical operation. | Other: Normal saline fluid group Plasma osmolality, acid base status and electrolytes after application up to 2000 ml of normal saline during neurosurgical operation |
Balanced fluid group The patients in this group will receive up to 2000 ml of balanced fluids during neurosurgical operation. | Other: Balanced fluid group Plasma osmolality, acid base status and electrolytes after application of up to 2000 ml balanced fluids during neurosurgical operation |
Критерии за допустимост
Възрасти, отговарящи на условията за проучване | 18 Years Да се 18 Years |
Полове, допустими за проучване | All |
Метод за вземане на проби | Probability Sample |
Приема здрави доброволци | Да |
Критерии | Inclusion Criteria: - Patients with brain tumor, meningeomas and vascular malformation. Exclusion Criteria: - Patients with signs of elevated intracranial pressure; History of kidney disease, History of heart disease |
Резултат
Първични изходни мерки
1. Changes in acid base pH status [During operation and immediately after operation]
Вторични изходни мерки
1. Changes in electrolytes (sodium and chloride) [During operation and immediately after operation]
Други изходни мерки
1. Plasma osmolality [Immediately after operation]