Beige Fat, Energy, and the Natriuretic Peptide System
Ключови думи
Резюме
Описание
Obesity represents a serious public health burden. Obese individuals experience increased risk of cardiovascular and metabolic cardiometabolic disease, including insulin diabetes, resistance, hypertension, and dyslipidemia. Obesity and obesity-associated cardiometabolic dysfunction are significant contributors to morbidity and mortality in Veterans. This indicates that obesity and cardiometabolic dysfunction are complex and multifactorial, and suggests that there are additional factors that contribute to the pathogenesis of obesity and its associated cardiometabolic risk that have been discovered. Moreover, some of the pharmacologic therapies for obesity can have adverse cardiovascular effects. Thus, it is crucial to improve the understanding of the multiple pathways contributing to the pathogenesis of obesity and obesity-associated cardiometabolic risk, including the identification of novel relevant pathways, in order to develop more effective treatments for these diseases. The proposed work will form a foundation for future high-impact studies of mechanisms for adiposity and cardiometabolic disease.
Дати
Последна проверка: | 03/31/2020 |
Първо изпратено: | 04/13/2020 |
Очаквано записване подадено: | 04/20/2020 |
Първо публикувано: | 04/21/2020 |
Изпратена последна актуализация: | 04/20/2020 |
Последна актуализация публикувана: | 04/21/2020 |
Действителна начална дата на проучването: | 04/12/2020 |
Приблизителна дата на първично завършване: | 06/29/2023 |
Очаквана дата на завършване на проучването: | 06/29/2023 |
Състояние или заболяване
Фаза
Групи за ръце
Arm | Интервенция / лечение |
---|---|
obese and lean individuals obese and lean individuals |
Критерии за допустимост
Възрасти, отговарящи на условията за проучване | 18 Years Да се 18 Years |
Полове, допустими за проучване | All |
Метод за вземане на проби | Probability Sample |
Приема здрави доброволци | Да |
Критерии | Inclusion Criteria: - Men and women ages 18-55 years - Body Mass Index (BMI) >= 18.5 and <25 kg/m2 (lean), or BMI 30 kg/m2 (obese) Exclusion Criteria: - Significant pulmonary, liver, or renal disease - Heart failure (any type) or unstable coronary artery disease - Diabetes Mellitus (Types 1 and 2) - Thyroid dysfunction - Active malignancy - Chronic inflammatory diseases, such as inflammatory bowel disease, hepatitis, rheumatoid arthritis - Postmenopausal status (for women) - Current use of medications likely to affect energy homeostasis, including glucocorticoids, amphetamines, and beta blockers - Currently pregnant or breastfeeding, or unwilling to avoid becoming pregnant or breastfeeding during study duration - Significant claustrophobia that would prevent the use of the metabolic cart as part of the study protocol - Hemoglobin A1c (HbA1c) >= 6.5% - Liver Function Tests (LFTs) elevated >3x upper limit of normal - Estimated Glomerular Filtration Rate (eGFR) <40 ml/min - Currently abnormal thyroid stimulating hormone (TSH) |
Резултат
Първични изходни мерки
1. adipose tissue gene expression of UCP1 (Uncoupling Protein 1)- differences by obesity status [Study Day 1]
Вторични изходни мерки
1. Associations of adipose tissue gene expression of UCP1 with natriuretic peptide markers [Study Day 1]
2. adipose tissue gene expression of UCP1 (Uncoupling Protein 1)- differences by race [Study Day 1]