Comparison of Liver and Renal Function After Transarterial Chemoembolization for Primary Hepatocellular Carcinoma With Iso-osmolar Contrast Media and Low Osmolar Contrast Media
Ключови думи
Резюме
Описание
This was a prospective, randomized, single centre, single-blind study. Patients were randomized (1:1) to use Low-osmolar contrast media or iso-osmolar contrast media for TACE.
On the morning of 2th and 5th days after TACE, a hematologic check was performed, the hematologic check including serum creatinine, blood urea nitrogen, direct bilirubin, indirect bilirubin, alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, lactate dehydrogenase, alkaline phosphatase, cholinesterase. Then, comparing them with the data before TACE.
Дати
Последна проверка: | 02/29/2012 |
Първо изпратено: | 03/19/2012 |
Очаквано записване подадено: | 03/25/2012 |
Първо публикувано: | 03/26/2012 |
Изпратена последна актуализация: | 03/29/2012 |
Последна актуализация публикувана: | 04/01/2012 |
Действителна начална дата на проучването: | 02/29/2012 |
Приблизителна дата на първично завършване: | 08/31/2012 |
Очаквана дата на завършване на проучването: | 08/31/2012 |
Състояние или заболяване
Фаза
Групи за ръце
Arm | Интервенция / лечение |
---|---|
low-osmolar contrast media Patients undergo TACE of low-osmolar contrast media on day 1. | |
iso-osmolar contrast media Patients undergo TACE of iso-osmolar contrast media on day 1. |
Критерии за допустимост
Възрасти, отговарящи на условията за проучване | 18 Years Да се 18 Years |
Полове, допустими за проучване | All |
Метод за вземане на проби | Probability Sample |
Приема здрави доброволци | Да |
Критерии | Inclusion Criteria: - 18-75 years; - PHC that could not be treated with surgery; - Patients with clear consciousness,Cooperation; - Informed consent: authorization and signature. Exclusion Criteria: - Preexisting dialysis; - Known hypersensitivity to the contrast media; - Complete portal vein thrombosis (main trunk or both branches); - With severe cardiovascular or renal disease; - Extensive arteriovenous shunting; - Insufficient function of the remaining liver (Child-Pugh class C). |
Резултат
Първични изходни мерки
1. Change from Baseline in serum creatinine, blood urea nitrogen, direct bilirubin, indirect bilirubin, alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, lactate dehydrogenase, alkaline phosphatase, cholinesterase. [Follow-up on the 2th and 5th days after TACE]