ELO Water In Diabetes Care For Enhancement Of Blood Sugar Control
Ключови думи
Резюме
Описание
Global diabetes mellitus prevalence is rapidly increasing. In 2015, IDF reported that Singapore has 12.8% of its population diagnosed with diabetes mellitus, of which more than 90 percent are type 2 diabetes with underlying insulin resistance. With the aging population and increasing prevalence of obesity and sedentary lifestyles, the prevalence is expected to continue to rise.
In vitro studies demonstrated that hypoxia creates a state of insulin resistance through HIF (Hypoxia Inducible Factor) transcription factor expression in adipocytes. Insulin sensitivity was shown to improve in type 2 diabetes patients and overweight non diabetic patients placed in a hyperbaric oxygen chamber.Increased water intake has been associated with lower HbA1c in the general population , and also with lower post-prandial glucose in type 2 diabetic individuals.
This study aims to evaluate the effects of 1.5 L daily of ELO water, a drinking water enriched with molecular oxygen in a stable form, with a similar volume of bottled drinking water, on glycaemic control in adults with type 2 diabetes in Singapore.
Дати
| Последна проверка: | 12/31/2019 |
| Първо изпратено: | 10/12/2019 |
| Очаквано записване подадено: | 10/12/2019 |
| Първо публикувано: | 10/15/2019 |
| Изпратена последна актуализация: | 01/21/2020 |
| Последна актуализация публикувана: | 01/26/2020 |
| Действителна начална дата на проучването: | 03/06/2017 |
| Приблизителна дата на първично завършване: | 05/27/2018 |
| Очаквана дата на завършване на проучването: | 05/27/2018 |
Състояние или заболяване
Интервенция / лечение
Dietary Supplement: Intervention Arm
Dietary Supplement: Control Arm
Фаза
Групи за ръце
| Arm | Интервенция / лечение |
|---|---|
| Experimental: Intervention Arm 1.5 L of ELO Water to be drunk daily for 24 weeks | Dietary Supplement: Intervention Arm oxygen-enriched water |
| Placebo Comparator: Control Arm 1.5 L of placebo bottled drinking water to be drunk daily for 24 weeks | Dietary Supplement: Control Arm bottled drinking water |
Критерии за допустимост
| Възрасти, отговарящи на условията за проучване | 21 Years Да се 21 Years |
| Полове, допустими за проучване | All |
| Приема здрави доброволци | Да |
| Критерии | Inclusion Criteria: Type 2 diabetes mellitus with HbA1c 8.0% to 11%, within the last 6 months Exclusion Criteria: 1. Type 1 diabetes patients 2. Pregnant or lactating women 3. Comorbid conditions requiring fluid restriction to below 1.5 L daily 4. Terminal illness with life expectancy less than 1 year |
Резултат
Първични изходни мерки
1. Improvement of glycaemic control [12 weeks]
2. Weight loss [12 weeks]
