Endogenous Estrogen and Coronary Heart Disease in Women
Ключови думи
Резюме
Описание
BACKGROUND:
Studies suggest that estrogen replacement therapy (ERT) lowers the risk of coronary heart disease in postmenopausal women. However, it is not known whether higher endogenous levels of estrogens in the postmenopausal period likewise have a protective effect.
DESIGN NARRATIVE:
The study used an existing resource of frozen blood samples from a cohort of 7,058 postmenopausal women enrolled between 1985 and 1991 for a study of endogenous hormones and cancer. The cohort was followed up to identify incident cases of coronary heart disease. One hundred thirty cases of coronary heart disease (defined as nonfatal myocardial infarction or death from coronary heart disease) were expected to occur by the end of follow-up. A nested case-control study was conducted in which each case was matched to two women from the cohort who were the same age as the case, donated blood around the same time, and were alive and free of heart disease as of the date of diagnosis of the case. Frozen serum samples from cases and their matched controls were analyzed for total estradiol, bioavailable estradiol (the estradiol fraction not bound to sex hormone binding globulin) estrone, total cholesterol, and high- and low-density lipoprotein cholesterol. Conditional logistic regression for matched sets were employed to determine whether estrogen levels were lower in the cases than their matched controls. The association between estrogen levels and cholesterol fractions was also investigated.
Дати
Последна проверка: | 11/30/2015 |
Първо изпратено: | 05/24/2000 |
Очаквано записване подадено: | 05/24/2000 |
Първо публикувано: | 05/25/2000 |
Изпратена последна актуализация: | 12/29/2015 |
Последна актуализация публикувана: | 12/30/2015 |
Действителна начална дата на проучването: | 03/31/1994 |
Приблизителна дата на първично завършване: | 02/28/1999 |
Състояние или заболяване
Фаза
Групи за ръце
Arm | Интервенция / лечение |
---|---|
Postmenopausal women with coronary heart disease | |
Postmenopausal women without coronary heart disease Matched in age to the women with heart disease |
Критерии за допустимост
Полове, допустими за проучване | Female |
Приема здрави доброволци | Да |
Критерии | No eligibility criteria |