Evaluation of Alpha-Lipoic Acid in Diabetic Cardiomyopathy

Inclusion Criteria:

- Male or female adult age ≥ 18 years

- patient with diagnosed type 2 diabetes (history of pathological hyperglycemia according to WHO and HbA1c standards >7% or ongoing treatment with oral antidiabetic agents).

- Patients with stable cardiomyopathy (no hospitalization in cardiology in the month before inclusion) with a left ventricular ejection fraction (LVEF) <50%.

- patient who has signed an informed consent form

- For women of childbearing age: effective contraception followed for at least 3 months before the start of the study and agreeing to keep it for the duration of the study.

- affiliation to a social security scheme.

Exclusion Criteria:

subjects:

- With a coronary event in the year before inclusion.

- With symptoms of cardiac ischemia at inclusion.

- Pregnant or breastfeeding woman

- Severe renal insufficiency

- Using antioxidant molecules in the 6 months prior to inclusion.

- Using drugs that can activate PPARs (Fibrates, Telmisartan, Enalaprilat).

- Using anti-inflammatory drugs.

- Suffering from acute infectious diseases and inflammatory diseases.

- Hypersensitivity or a history of hypersensitivity reaction to gadoteric acid, meglumine or any drug containing gadolinium.

Non-inclusion criteria related to MRI:

- with an implanted vascular stent less than 6 weeks before the examination;

- carrier of an implanted biomedical device deemed "not safe" or "unsafe" in the list: http://www.mrisafety.com/TheList_search.asp;

- Beneficiary of an acquisition procedure that does not respect the conditions required by "conditional" use in a subject carrying an implanted biomedical material considered "conditional" in the list: http://www.mrisafety.com/TheList_search.asp;

- carrier of a ferromagnetic intraocular or intracranial foreign body close to the nerve structures;

- carrying biomedical equipment such as a cardiac, neural or sensory pacemaker (cochlear implant) or a ventricular bypass valve without medical and paramedical supervision trained to perform MRI in these subjects;