Infections of the Central Nervous System
Ключови думи
Резюме
Описание
The specific aims of the study include:
1. To assess the incidence, the diagnostic workup, and the treatment characteristics of patients with suspected and confirmed ME.
2. To examine clinical differences between patients with initially suspected and confirmed infectious Meningitis (ME) versus those with suspected but not confirmed infectious ME.
3. To evaluate potentially prognostic factors for pathological CT findings (especially expanding cerebral mass lesions) in patients with suspected infectious ME.
4. To identify a specific group of patients that benefit from cranial CT prior to LP.
5. To examine possible complications (e.g., hematoma, postpuncture headache, cerebral herniation, …) of lumbal punction (LP) and their correlations to pathologic signs on cranial CT.
6. To compare the outcome between patients with suspected infectious ME and cranial CT prior to LP versus patients without prior cranial CT.
Дати
| Последна проверка: | 03/31/2020 |
| Първо изпратено: | 02/25/2019 |
| Очаквано записване подадено: | 02/25/2019 |
| Първо публикувано: | 02/26/2019 |
| Изпратена последна актуализация: | 04/13/2020 |
| Последна актуализация публикувана: | 04/14/2020 |
| Действителна начална дата на проучването: | 02/28/2019 |
| Приблизителна дата на първично завършване: | 08/31/2019 |
| Очаквана дата на завършване на проучването: | 08/31/2019 |
Състояние или заболяване
Интервенция / лечение
Other: collection of patient data
Фаза
Критерии за допустимост
| Възрасти, отговарящи на условията за проучване | 18 Years Да се 18 Years |
| Полове, допустими за проучване | All |
| Метод за вземане на проби | Probability Sample |
| Приема здрави доброволци | Да |
| Критерии | Inclusion Criteria: - suspected or confirmed infectious meningitis and/or encephalitis as principal and/or secondary diagnosis from January 2006 to December 2017 Exclusion Criteria: - patients with the diagnosis of meningitis/encephalitis confirmed prior to hospital admission |
Резултат
Първични изходни мерки
1. incidence of patients with suspected and confirmed ME (number) [single time point assessment during hospital stay (up to 4 weeks)]
2. Pathologic CT findings [single time point assessment during hospital stay (up to 4 weeks)]
3. Pathologic CT findings constituting a risk factor for herniation after performance of LP [single time point assessment during hospital stay (up to 4 weeks)]
Вторични изходни мерки
1. hematoma (number) [single time point assessment during hospital stay (up to 4 weeks)]
2. Glasgow Outcome Score [single time point assessment during hospital stay (up to 4 weeks)]
3. postpuncture headache (number) [single time point assessment during hospital stay (up to 4 weeks)]
4. cerebral herniation (number) [single time point assessment during hospital stay (up to 4 weeks)]
5. pathological CT findings (number) [single time point assessment at hospitalisation (Day1)]
6. kind of medication [single time point assessment during hospital stay (up to 4 weeks)]
7. Intensive Care Delirium Screening Checklist (ICDSC) [single time point assessment during hospital stay (up to 4 weeks)]
8. Death during hospital stay [single time point assessment during hospital stay (up to 4 weeks)]
9. Return to premorbid functional baseline [single time point assessment during hospital stay (up to 4 weeks)]
