Intervention With Legume Kernel Fibre in Healthy Subjects
Ключови думи
Резюме
Описание
Dietary fibre is suspected to effect the faecal concentration and excretion of bile acids by binding the bile acids and by increasing the faecal mass. Bile acids, especially the secondary bile acids, are potential risk factors for colorectal cancer. A high bile acid-binding ability of fibre could lead to lower serum cholesterol concentrations by interrupting the enterohepatic circulation. There is evidence that the consumption of legume kernel fibre, containing both soluble and insoluble fibre fractions, may beneficially modify bowel health.
Seventy-eight healthy volunteers were enrolled. Seventy-six subjects (mean age of 24 years, 55 women and 21 men) completed the double-blind, randomized crossover trial. After two weeks run-in period, half of the volunteers consumed 25 g of legume fibres (Boregine, TypTop or Soy fibre) every day, and the other half received a reference fibre product (citrus fibre, Herbacel AQ Plus) for a period of two weeks. After two weeks wash-out the intervention changed between the groups.
At the end of each period a quantitative stool and urine collection took place and fasting blood samples were drawn.
Дати
Последна проверка: | 11/30/2009 |
Първо изпратено: | 12/16/2009 |
Очаквано записване подадено: | 12/17/2009 |
Първо публикувано: | 12/20/2009 |
Изпратена последна актуализация: | 11/04/2012 |
Последна актуализация публикувана: | 11/05/2012 |
Действителна начална дата на проучването: | 06/30/2007 |
Приблизителна дата на първично завършване: | 11/30/2007 |
Очаквана дата на завършване на проучването: | 11/30/2007 |
Състояние или заболяване
Интервенция / лечение
Dietary Supplement: pure fibre-product
Dietary Supplement: reference fibre
Фаза
Групи за ръце
Arm | Интервенция / лечение |
---|---|
Experimental: TypTop Lupinus albus Typ Top (lupin kernel fibre, dietary fibre content: 83%) | |
Experimental: Soy fibre Glycine max Hefeng (soy fibre; dietary fibre content: 77%) | |
Experimental: Boregine Lupinus angustifolius Boregine (lupin kernel fibre, dietary fibre content: 87%) |
Критерии за допустимост
Възрасти, отговарящи на условията за проучване | 20 Years Да се 20 Years |
Полове, допустими за проучване | All |
Приема здрави доброволци | Да |
Критерии | Inclusion Criteria: - age 20-45 years - healthy subjects Exclusion Criteria: - intake of pharmaceuticals and nutritional supplements - allergy against legumes - intolerance against milk protein - pregnancy, lactation - chronic diseases |
Резултат
Първични изходни мерки
1. Changes of serum lipids (cholesterol metabolism) [after 2, 4 and 8 weeks]
Вторични изходни мерки
1. Changes of general excretion parameters, neutral sterols, bile acids, short-chain fatty acids, fibre excretion [after 2, 4 and 8 weeks]