Phase 2a Obesity Study of Oral Doses of Oleoyl-Estrone (MP-101)

Inclusion Criteria:

- Be a male or female between the ages of 18 and 65 years, inclusive

- Female subjects must be either surgically sterile or at least 2 years postmenopausal

- Have a BMI of 27 - 38.9, inclusive

- Have a stable weight for the past 30 days per subject report

- Be otherwise healthy and have an acceptable medical history

- Have negative urinalysis test results for drugs of abuse and alcohol

- Have the ability to understand the requirements of the study, have provided written informed consent and agree to abide by the study restrictions

- Exhibit stable behavior patterns with regard to smoking and exercise

- Subject who has at least one factor of the metabolic syndrome

Exclusion Criteria:

- Be pregnant or nursing

- Have taken exclusionary medication in the past 30 days

- Have any clinically significant abnormal laboratory test as determined by the investigator

- Have a clinically significant illness during the 30 days before enrollment

- Have a history of testing positive for Hepatitis B virus, Hepatitis C virus, or HIV

- Have a confirmed diagnosis or history of cancer, with the exception of nonmelanoma skin cancer

- Have a previous diagnosis of diabetes

- Be otherwise unsuitable for the study, in the opinion of the investigator

- Have an allergy to safflower seeds or its byproducts (e.g., safflower oil)

- Have any postmenopausal bleeding within the last 6 months

- Have been involved in a formal or informal (self-imposed) diet regimen within the last 30 days

- Currently working night shifts

- Have a history of known multiple miscarriages