Presentations of Hyperandrogenic Phenotypes in Taiwanese Women
Ключови думи
Резюме
Описание
STUDY DESIGN, SIZE, DURATION:A retrospective study in 160 Taiwanese women with HA and 165 women without HA, with medical records reviewed from 2009 up to 2012. The hyperandrogenic women were classified into four groups (TT, A4, FAI, and DHEA-S) according to independent abnormally elevated androgen measures each above its cut-off value, and the groups were compared with each other and with controls.
PARTICIPANTS/MATERIALS, SETTING, METHODS: This study was performed in the Reproductive Endocrinology Clinic at Wan Fang Medical Center in Taipei, Taiwan. Anthropometric, metabolic, endocrine, and IR components as well as lipid accumulation product (LAP) index were compared between the groups. IR was assessed with the following markers: fasting glucose and insulin levels, oral glucose tolerance test, glucose-to-insulin ratio and homeostasis model assessment of IR index (HOMA-IR).
Дати
| Последна проверка: | 10/31/2013 |
| Първо изпратено: | 04/04/2013 |
| Очаквано записване подадено: | 09/10/2013 |
| Първо публикувано: | 09/11/2013 |
| Изпратена последна актуализация: | 11/04/2013 |
| Последна актуализация публикувана: | 11/05/2013 |
| Действителна начална дата на проучването: | 08/31/2012 |
| Приблизителна дата на първично завършване: | 02/28/2013 |
| Очаквана дата на завършване на проучването: | 06/30/2013 |
Състояние или заболяване
Фаза
Групи за ръце
| Arm | Интервенция / лечение |
|---|---|
| Controls patients who have all androgens (TT, A4, FAI, and DHEA-S) lower than their cut-off values | |
| Total Testosterone >= 2.39 Patients who have only total testosterone higher than its cut-off value; (TT) >=2.39 | |
| Androstenedione >= 2.99 Patients who have only androstenedione higher than its cut-off value; (A4) >=2.99 | |
| Free Androgen Index >= 6.53 Patients who have only free androgen index higher than its cut-off value; (FAI) >=6.53 | |
| DHEAs >= 181.55 Patients who have only dehyroepiandrosterone sulfate higher than its cut-off value; (DHEA-S)>=181.55 |
Критерии за допустимост
| Възрасти, отговарящи на условията за проучване | 13 Years Да се 13 Years |
| Полове, допустими за проучване | Female |
| Метод за вземане на проби | Probability Sample |
| Приема здрави доброволци | Да |
| Критерии | Inclusion Criteria: - Hyperandrogenic women who were classified into four groups: - Total testosterone (TT), - Androstenedione (A4), - Free androgen index (FAI), - and Dehydroepiandrosterone sulphate(DHEA-S). - According to abnormally elevated androgen measures each above its cut-off value, and non hyperandrogenic women (who had all androgens below their cut-off values) Exclusion Criteria: - None of the women studied had - Hypogonadotropic hypogondism, - Hyperprolactinemia, - Congenital adrenal hyperplasia, - Premature ovarian failure, - Androgen-secreting tumors, - Cushing's syndrome, - or any other endocrine or systemic disease that may affect the reproductive function, - or any disorders of the uterus (e.g. Asherman's syndrome and Mullerian genesis) and chromosomal anomalies (e.g. Turner's syndrome). - In addition, we excluded females who had - Experienced menarche less than three years preceding the study start, - or who had day 3 FSH > 15 mIU/ml, as well as women with insufficient clinical/biochemical records, - and women with ovarian cysts or tumors in an ultrasonographic examination. |
Резултат
Първични изходни мерки
1. Clinical and Biochemical Presentations of Distinctive Types of Biochemical Hyperandrogenism in Premenopausal Taiwanese Women [A retrospective study in 160 Taiwanese women with HA and 165 women without HA, with medical records reviewed from January 1, 2009, through July 21, 2012 (up to 3.5 years)]
