RESIST! Blood-flow Restriction Resistance Training for Improving Insulin Sensitivity in Type 2 Diabetes
Ключови думи
Резюме
Описание
Type 2 diabetes (T2D) is characterized by an increasing insensitivity of muscle, fat and liver cells to the hormone insulin. About 9% of the global population is affected by this condition and mortality risk is twice as high in individuals with diabetes compared to similar-aged people without diabetes.
Muscle is of particular importance for glucose homeostasis, since in healthy people it accounts for 80-90% of postprandial insulin-stimulated glucose disposal. After cellular uptake of glucose by the specialized glucose transporter 4 (GLUT4), glucose is phosphorylated and stored as glycogen. In individuals with obesity or T2D, the capacity for insulin to facilitate glucose uptake and glycogen synthesis is impaired. This reduced response of a given insulin concentration to exert its biological effect is termed insulin resistance. Subsequent diminished insulin secretion due to β-cell failure results in fasting hyperglycemia and overt diabetes. Importantly, muscle insulin resistance is the initial defect occurring in the development of T2D and precedes the clinical development of the disease by up to 20 years.
Thus, the preservation of skeletal muscle function is essential for people with T2D who have an increased risk of sarcopenia. On the one hand high intensity resistance training (HIT) with 80 % one-repetition maximum (%1-RM) is a well-recognized strategy to improve muscle strength and glycemic control for individuals with T2D, on the other hand elderly or obese people may not be able to tolerate these high loads. Blood flow restriction training (BFRT) with low loads (20-30% 1-RM) has consistently demonstrated comparable effects to HIT and seems to be a promising alternative to increase muscle function.
During the BFRT the muscle becomes hypoxic due to a brief occlusion of venous blood flow using a tourniquet while exercising. Consequently metabolites like lactate, growth hormone (GH) and insulin like growth factor (IGF-1) are released and result in muscle hypertrophy through activating the collagen synthesis and the recruitment of satellite cells. Furthermore cell swelling based on venous blood pooling, reactive hyperemia and metabolite accumulation has been shown to increase protein synthesis by activating the mammalian Target of Rapamycin Complex 1 (mTORC1) pathway. Also, BFRT increases the level of reactive oxygen species (ROS) which may lead to higher glucose uptake during exercise. Last but not least higher threshold motor units (fast twitch fibers) are recruited due to hypoxia and metabolite accumulation.
Although there is a significant inverse relationship between muscle strength and the risk of cardiovascular mortality, cardiovascular adaptations to resistance training are under-explored and poorly understood.
The study therefore aims to investigate the metabolic and cardiovascular effects of BFRT with low loads in individuals with T2D.
Дати
| Последна проверка: | 12/31/2019 |
| Първо изпратено: | 12/09/2019 |
| Очаквано записване подадено: | 01/06/2020 |
| Първо публикувано: | 01/08/2020 |
| Изпратена последна актуализация: | 01/06/2020 |
| Последна актуализация публикувана: | 01/08/2020 |
| Действителна начална дата на проучването: | 10/27/2019 |
| Приблизителна дата на първично завършване: | 12/30/2020 |
| Очаквана дата на завършване на проучването: | 06/30/2021 |
Състояние или заболяване
Интервенция / лечение
Other: Blood-flow restriction resistance training
Other: Classical resistance training
Фаза
Групи за ръце
| Arm | Интервенция / лечение |
|---|---|
| Experimental: Blood-flow restriction resistance training Resistance training with low loads (15-30% RM) in combination with a brief occlusion of venous blood flow using a tourniquet while exercising. | Other: Blood-flow restriction resistance training Training program: After 10 minutes of warm-up the participant performs three exercises with BFRT for the lower extremities. The intensity is about 15-30% of 1-RM. |
| Experimental: Classical resistance training Resistance training with high loads (60-80% RM). | Other: Classical resistance training Training program: After warm-up the participant performs three exercises for lower body. The intensity is about 60-80% of 1-RM. |
Критерии за допустимост
| Възрасти, отговарящи на условията за проучване | 30 Years Да се 30 Years |
| Полове, допустими за проучване | All |
| Приема здрави доброволци | Да |
| Критерии | Inclusion Criteria: - Male and female, age between ≥ 30 and ≤ 69 years - Individuals with type 2 diabetes - BMI: 19-35 kg/m² Exclusion Criteria: - Acute infections in the last 2 weeks - Weight fluctuations (> 10% in the last 6 month) - Therapy with Glitazone, Beta blocker, Insulin - Malignant cancer - Heart diseases (angina pectoris, myocardial infarction, acute myocarditis or pericarditis, cardiac wall aneurysms/ stenose, untreated hypotension or hypertension, aortic stenosis, stroke, cardiac insufficiency, NYHA-class ≥II, heart arrhythmia, disturbances of blood circulation in extremities, venous insufficiency, varicose veins) - Diabetic neuropathy - Respiratory disease (COPD, Gold grade ≥II) - Serious heart, kidney or liver disease: - New York Heart Association-Classification (NYHA) stage ≥ II - creatinine ≥ 1.6 mg / dl - Aspartate Aminotransferase (AST) or Alanine Aminotransferase (ALT) ≥ two-fold upper reference value - Anemia (Hb <12g / l), blood donation in the last 3 month - Disease of the immune system (leucocytes <5000/μl) - Application of immunomodulatory agents (Glucocorticoids, Antihistamine, Acetylsalicylic acid) - Application of antithrombotic agents (Anticoagulant) - Blood clotting disorders (abnormally levels of thrombocytes [<150.000, >450.000], Partial thromboplastin time (PTT) [26-36 s], Quick [70-120%]) or wound healing - Thyroid disease (untreated hypothyroidism or hyperthyroidism, treatment with thiamazol) - Epilepsy - Application of drugs which can manipulate the thermoregulation (Antipsychotic) - Rosacea - Vitamine supplement (with the las 4 weeks) - Cigarettes (or non-smokers <1 year) alcohol consumption (men> 30 g / d, women> 20 g / d), drug abuse - Severe psychiatric illness or addiction - Risk for/ or HIV or Hepatitis B or C - Shift work or anormal circadian rhythm - Muscle diseases, orthopedic restrictions - Hypersensitivity to local anaesthetic - Pregnancy, lactation - Metallic and magnetic implants (for example, mechanical heart valves, joint prostheses, clip after vascular surgery, middle and inner ear implants or fresh dental implants) - Claustrophobia - Hypohidrosis - Participation in another intervention study within the last 3 month |
Резултат
Първични изходни мерки
1. Change in insulin sensitivity by blood-flow restriction or classical resistance training [Before and after 12 weeks of training (intervention)]
Вторични изходни мерки
1. Changes in skeletal muscle mass by blood-flow restriction or classical resistance training [Before and after 12 weeks of training (intervention)]
Други изходни мерки
1. Changes in skeletal muscle strength by blood-flow restriction or classical resistance training [Before and after 12 weeks of training (intervention)]
