Retinal Microvascularization and Cardiovascular Disease

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Centre Hospitalier Universitaire Dijon

КЛИНИЧНО ИЗСЛЕДВАНЕ: NCT03551717

BioSeek: nct03551717

Ключови думи

Резюме

The main objective of this study is to investigate whether there are links between the blood vessels of the retina as a whole and heart and/or vascular diseases (cardiovascular diseases).

The arteries and veins of the retina are, like the large vessels of the human body (aorta, coronary, cerebral arteries), exposed to the complications of hypertension, diabetes, obesity, dyslipidemia (abnormal blood lipid profile) or tobacco. Several studies have shown that changes in retinal vessels (microvascularization) generally occur several years before damage to large peripheral vessels (macrovascularization). The study of the vessels of the retina is now possible thanks to simple and non-invasive examinations of photographs (not creating any lesion). They allow a painless evaluation of the vessels in the retina.

Ultimately, if this study is conclusive, the patient's cardiovascular risk could be evaluated simply by analysis of the vessels of the retina.

The study is being conducted in the ophthalmology and cardiology departments of Dijon University Hospital. In total, the investigators wish to include approximately 510 patients who present cardiovascular risk factors (255 low risk patients recruited in the ophthalmology department and 255 high risk patients hospitalized in the cardiology department).

All patients participating in the study will be asked to visit the ophthalmology department for a complete examination of the retina.

Дати

Последна проверка:	04/30/2020
Първо изпратено:	05/28/2018
Очаквано записване подадено:	06/07/2018
Първо публикувано:	06/10/2018
Изпратена последна актуализация:	05/21/2020
Последна актуализация публикувана:	05/26/2020
Действителна начална дата на проучването:	03/13/2018
Приблизителна дата на първично завършване:	04/18/2019
Очаквана дата на завършване на проучването:	04/18/2019

Състояние или заболяване

High Cardiovascular Risk Patients

Low Cardiovascular Risk Patients

Интервенция / лечение

Other: Optical Coherence Tomography angiography

Other: Fundus

Other: High cardiovascular risk patients

Фаза

Групи за ръце

Arm	Интервенция / лечение
High cardiovascular risk patients Adult patients hospitalized in the Cardiology Department of the University Hospital of Dijon Burgundy for acute coronary syndrome, patients between D1 and D5 of acute coronary syndrome, who can be moved for an ophthalmology consultation where the retinal imaging is done (heart monitoring in the presence of an experienced cardiologist if necessary)	Other: High cardiovascular risk patients Only for 50 patients, 3 months after the initial cardiovascular event
Low cardiovascular risk patients Adult patients recruited in the Ophthalmology Department of the University Hospital of Dijon Burgundy following a standard consultation for cataract surgery. The age balance of the patients included in the two groups will be checked regularly.

Критерии за допустимост

Възрасти, отговарящи на условията за проучване	18 Years Да се 18 Years
Полове, допустими за проучване	All
Метод за вземане на проби	Non-Probability Sample
Приема здрави доброволци	Да
Критерии	Inclusion Criteria: - Person who gave oral consent - High cardiovascular risk group: Adult patients hospitalized in the Cardiology Department of the University Hospital of Dijon Burgundy for acute coronary syndrome, patients between D1 and D5 of acute coronary syndrome, who can be moved for an ophthalmology consultation where the retinal imaging is done (heart monitoring in the presence of an experienced cardiologist if necessary) - Low cardiovascular risk group: Adult patients over 40 years of age recruited in the Ophthalmology Department of the University Hospital of Dijon Burgundy following a standard consultation for cataract surgery, ocular surface pathologies and optical correction. Exclusion Criteria: - Person not affiliated to national health insurance - Patient refusal - Minor patient - Protected patient - Ophthalmological history (macular vascular or degenerative disorders)

Резултат

Първични изходни мерки

1. Surface of the avascular zone in the central retina [Baseline]

Retinal Microvascularization and Cardiovascular Disease

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