The Effect of Childhood Dyslipidemia on Endothelial and Renal Function
Ключови думи
Резюме
Описание
In children recruited in the study, family history of dyslipidemia or premature cardiovascular disease will be recorded. Furthermore, anthropometric and clinical characteristics will be noted and lipid measurements will be obtained at recruitment after a fasting period.
The investigators will test in children the flow-mediated dilation (FMD) which assesses the vasodilation due to the production of nitric oxide from the endothelium in response to occlusion-induced hyperaemia of the branchial artery and the carotid intima-media thickness (cIMT). These non-invasive ultrasound indices detect early vascular damage.
Renal function will be assessed in children with dyslipidemia by a new marker in serum, cystatin C, which is more accurate and reliable than creatinine. Also, creatinine serum levels and estimated glomerular filtration rate (eGFR) will be evaluated. Additionally, total protein, albumin, electrolyte and β2-microglobulin excretion in urine will be measured.
Дати
| Последна проверка: | 02/29/2020 |
| Първо изпратено: | 02/19/2019 |
| Очаквано записване подадено: | 02/25/2019 |
| Първо публикувано: | 02/26/2019 |
| Изпратена последна актуализация: | 03/22/2020 |
| Последна актуализация публикувана: | 03/23/2020 |
| Действителна начална дата на проучването: | 04/02/2017 |
| Приблизителна дата на първично завършване: | 04/02/2020 |
| Очаквана дата на завършване на проучването: | 04/02/2020 |
Състояние или заболяване
Фаза
Групи за ръце
| Arm | Интервенция / лечение |
|---|---|
| Dyslipidemia group Children and adolescents with dyslipidemia | |
| Control group Children and adolescents without dyslipidemia |
Критерии за допустимост
| Възрасти, отговарящи на условията за проучване | 7 Years Да се 7 Years |
| Полове, допустими за проучване | All |
| Метод за вземане на проби | Non-Probability Sample |
| Приема здрави доброволци | Да |
| Критерии | Inclusion Criteria: - Children and adolescents aged 7 to 17 years - Dyslipidemia (serum levels of LDL-cholesterol ≥95th percentile or serum levels of triglycerides ≥95th percentile or serum levels of HDL-cholesterol ≤5th percentile for age and sex) Exclusion Criteria: - History of renal disease - Dyslipidemia caused by nephrotic syndrome or chronic kidney disease - Chronic use of medication - Acute or chronic inflammatory process |
Резултат
Първични изходни мерки
1. Flow-mediated dilation of the branchial artery [At subject enrollment]
2. Carotid intima-media thickness [At subject enrollment]
3. Measurement of cystatin C in serum [At subject enrollment]
Вторични изходни мерки
1. Number of participants with abnormal levels of lipoprotein a. [At subject enrollment]
2. Levels of β2-microglobulin in urine [At subject enrollment]
3. Serum creatinine levels [At subject enrollment]
4. Assessment of eGFR [At subject enrollment]
