To Study Polycystic Ovary Syndrome in Taiwanese Women
Ключови думи
Резюме
Описание
1. Method
1. This study was approved by the Institutional Review Board of the Wan Fang Medical Center at Taipei Medical University (WF99041, approved August 2010) and performed at the Reproductive Endocrinology Clinic at the Wan Fang Medical Center from 31 August 2010 to 31 August 2011. The following women were excluded: (i) women who had been diagnosed with hyperprolactinemia, hypogonadotropic hypogonadism, premature ovarian failure, congenital adrenal hyperplasia, androgen-secreting tumor,Cushing's syndrome, disorders of the uterus and chromosomal anomalies; (ii) women who were less than three years past menarche or who were older than 45 years; (iii) women who received hormones or medication for major medical diseases (diabetes or cardiovascular disease); and (iv) women who had had ovarian cysts or ovarian tumors identified by ultrasonographic examination.
2. Statistical analysis: We used chi-squared and Fisher's exact tests to perform categorical comparisons and ANOVA to compare the continuous variables. The means of more than two groups were compared using one-way ANOVA and post hoc Dunnett's t-test with equal variances not assumed.
Дати
Последна проверка: | 11/30/2015 |
Първо изпратено: | 12/06/2010 |
Очаквано записване подадено: | 12/07/2010 |
Първо публикувано: | 12/08/2010 |
Изпратена последна актуализация: | 12/07/2015 |
Последна актуализация публикувана: | 01/12/2016 |
Дата на първите подадени резултати: | 11/27/2013 |
Дата на първите подадени резултати от QC: | 12/07/2015 |
Дата на първите публикувани резултати: | 01/12/2016 |
Действителна начална дата на проучването: | 07/31/2010 |
Приблизителна дата на първично завършване: | 05/31/2013 |
Очаквана дата на завършване на проучването: | 05/31/2013 |
Състояние или заболяване
Фаза
Групи за ръце
Arm | Интервенция / лечение |
---|---|
Control The normal reproductive-aged women | |
PCOS Women who met the 2003 Rotterdam criteria, which require a minimum of two of the following three criteria:
Oligo- or anovulation
Clinical and/or biochemical signs of hyperandrogenism
Polycystic ovaries and exclusion of other etiologies (congenital adrenal hyperplasia, androgen-secreting tumors, Cushing's syndrome) |
Критерии за допустимост
Възрасти, отговарящи на условията за проучване | 15 Years Да се 15 Years |
Полове, допустими за проучване | Female |
Метод за вземане на проби | Probability Sample |
Приема здрави доброволци | Да |
Критерии | Inclusion Criteria: - women at reproductive age - women with PCOS and women without PCOS. Exclusion Criteria: - young women who had their menarche less than 3 years - women older than 45 years old, Amenorrhea of menopause, hyperglycemia, hyperthyroidism, hypothyroidism, heart failure, lung failure, renal failure, anemia, dystrophy, gonitis. |
Резултат
Първични изходни мерки
1. Total Testosterone [1 year]
2. BMI [1 year]
3. Fasting Insulin [1 year]
4. Fasting Glucose [1 year]
5. Two Hour Glucose [1 year]
6. Homeostasis Model Assessment Insulin Resistance Index (HOMA-IR) [1 year]
7. Cholesterol [1 year]
8. Triglycerides [1 year]
9. HDL [1 year]
10. LDL [1 year]
11. Impaired Glucose Tolerance [1 years]