Vitamin D Supplementation for Treatment of Dyslipidemia
Ключови думи
Резюме
Описание
Vitamin D receptor gene mutations have been associated with increased incidence of arterial hypertension. While, hyperlipidemia and lipoprotein oxidation in bone is leading to osteoporosis by inhibiting osteoblastic differentiation It has been reported that vitamin D supplementation has shown pro-atherogenic effects in rats, and its deficiency is associated with the deterioration of atherogenesis These contradictory findings on the progression of atherosclerosis were examined in this study.
Aim: This study will be conducted to assess possible reduction in lipid profile (LDL-Triglycerides-cholesterol) among pre-menopausal women in vitamin D group compared to standard treatment group after 3 months & 6 month of follow up as prophylaxis step for atherosclerosis.
Subject and methods: Randomized clinical trial with double blinding will be performed on two groups study group and control group. The cases will recruited from outpatient clinic of medicine department in Mansoura university Hospital.
Sample size: based on pilot study after start of trial
Study groups:
Intervention group: High dose vitamin D3 IM treatment group according to vitamin D3 level after laboratory assessment.
Standard treatment group: Balanced diet mix of Carbohydrate, lipid, protein and fat diet minerals and vitamins for same period of follow up.
Inclusion criteria : pre-menopausal females (35-45 years old)
- No co morbidity
- Negative history of contraceptive pills or drug history of cholesterol lowering drugs
- Absent chronic diseases
There is possible recruiting of postmenopausal women according to difficulty in finding pre-menopausal women.
Methods: study patients will be subjected to:
- Full history taking,clinical examination, Anthropometric measurements.
- Laboratory investigations: Vitamin D3 assessment for all study patients.
Outcome that will be measured before and after follow up:
1. Serum 25 hydroxy Vitamin D3
2. C reactive protein
3. Serum Calcium level
4. Complete Lipid profile: LDL-HDL-Triglycerides -Total cholesterol quantitative and qualitative assessment.Patient will be fasting for at least 12-14 h then 5 mL venous blood sample will be drawn from each patient into plain tube and left to clot. Serum for routine analysis and the other aliquot will be stored at -21°C analysis will be separated by centrifugation into two aliquots; one will be used
Дати
| Последна проверка: | 07/31/2018 |
| Първо изпратено: | 04/25/2017 |
| Очаквано записване подадено: | 04/26/2017 |
| Първо публикувано: | 04/27/2017 |
| Изпратена последна актуализация: | 08/16/2018 |
| Последна актуализация публикувана: | 08/20/2018 |
| Действителна начална дата на проучването: | 03/31/2017 |
| Приблизителна дата на първично завършване: | 12/30/2018 |
| Очаквана дата на завършване на проучването: | 06/30/2019 |
Състояние или заболяване
Интервенция / лечение
Drug: Treatment
Other: Control
Фаза
Групи за ръце
| Arm | Интервенция / лечение |
|---|---|
| Experimental: Treatment Single high dose IM VIT D | Drug: Treatment Single high dose vitamin D3 in treatment of dyslipedemia |
| Active Comparator: Control Usual diet mix of carbohydrates - lipid - protein - minerals & vitamins | Other: Control Mixed diet of carbohydrate and protein |
Критерии за допустимост
| Възрасти, отговарящи на условията за проучване | 35 Years Да се 35 Years |
| Полове, допустими за проучване | Female |
| Приема здрави доброволци | Да |
| Критерии | Inclusion Criteria: - premenopausal females (35-45 years) Exclusion Criteria: - no co morbodity - no lipid lowering drugs or contraceptive pills |
Резултат
Първични изходни мерки
1. serum levels of LDL-HDL-Total cholesterol-triglecerides [3 months-6 months]
