Aerobic exercise reduced oxidative stress in saliva of persons with Down syndrome.

The aim of this investigation was to examine the effect of aerobic exercise (AE) on uric acid (UA), total antioxidant activity (TAA), oxidative stress (OS) and nitrite a stable nitric oxide (NO) metabolite in saliva from persons with Down syndrome (DS). Stimulated saliva was sampled from 12 participants 1 hour before and immediately after a 1,600-meter walking test. Uric acid (UA) was assayed by enzymatic method, TAA by ABTS method, lipid hydroperoxides (OS marker) by the ferrous iron/xylenol orange (FOX) method and nitrite concentration by the Griess reaction. Aerobic exercise (AE) caused a decrease in salivary lipid hydroperoxides in persons with DS (p = 0.001). Aerobic exercise (AE), however, did not affect salivary UA, TAA, and nitrite. This result suggested that AE can be considered as a way to reduce the OS in persons with DS, particularly in the mouth cavity.