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antimanic/епилептични припадъци
Линкът е запазен в клипборда
Страница 1 от 18 резултата
Mechanisms of the Antimanic Effect of Electroconvulsive Therapy.
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The available evidence indicates that electroconvulsive therapy (ECT) has a marked and specific antimanic effect. Data on change in seizure threshold during ECT and acute effects of ECT on cerebral blood flow are presented in support of the view that the therapeutic effects of ECT are related to its
Protective effects of lithium chloride on seizure susceptibility: Involvement of α2-adrenoceptor.
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For more than 60years, lithium has been the mainstay in the treatment of mental disorders as a mood stabilizer. In addition to the antimanic and antidepressant responses, lithium also shows some anticonvulsant properties. In spite of the ascertained neuroprotective effects of this alkali metal, the
Agmatine enhances the anticonvulsant effect of lithium chloride on pentylenetetrazole-induced seizures in mice: Involvement of L-arginine/nitric oxide pathway.
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After nearly 60years, lithium is still the mainstay in the treatment of mood disorders. In addition to its antimanic and antidepressant effects, lithium also has anticonvulsant properties. Similar to lithium, agmatine plays a protective role in the central nervous system against seizures and has
Positive and negative psychiatric effects of antiepileptic drugs in patients with seizure disorders.
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Antiepileptic drugs (AEDs) have various mechanisms of actions and therefore have diverse anticonvulsant, psychiatric, and adverse effect profiles. Two global categories of AEDs are identified on the basis of their predominant psychotropic profiles. One group has "sedating" effects in association
Time course of clinical effects of carbamazepine: implications for mechanisms of action.
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The onset of therapeutic effectiveness of carbamazepine is generally very rapid in the treatment of seizure and paroxysmal pain disorders, shows some lag in the treatment of mania, and exhibits the longest lag in depression. These time course variations may indicate that different mechanisms
Dyscontrol syndrome: long-term follow-up.
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This is a 38- to 57-month follow-up of 50 patients referred for drug-activated electroencephalograms (EEG) because of the suspicion that a limbic complex partial seizure was a crucial mechanism behind their episodic behavior. Hence, an anticonvulsant regimen might be an effective therapeutic option.
Zonisamide: a new antiepileptic drug.
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Zonisamide (ZNS) is a relatively new antiepileptic medication currently available in Japan. Attempts to market the drug in the United States were thwarted by reports of nephrolithiasis by European and American investigators. However, successful marketing of the drug in Japan has resulted in a
An open case series on the utility of tiagabine as an augmentation in refractory bipolar outpatients.
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BACKGROUND
Tiagabine (Gabitril) is a GABA uptake inhibitor recently introduced in the United States as an adjunctive treatment for partial complex seizures. Three published studies have addressed the use of tiagabine for bipolar disorder (BPD); two described positive results and one negative
Unmodified Electroconvulsive Therapy of Acute Mania: A Retrospective Naturalistic Study.
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In this retrospective naturalistic study, clinical records were reviewed to examine the effects of unmodified electroconvulsive therapy (ECT) in 30 manic patients at a psychiatric institute in India. Twenty of the patients were experiencing their first episode of a major mood disorder. ECT was
Magnesium sulfate and sodium valproate block methylphenidate-induced hyperlocomotion, an animal model of mania.
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Magnesium sulfate (MgSO4) is used to treat and prevent eclamptic seizures, and several anticonvulsant drugs (e.g., sodium valproate) are clinically effective antimanic drugs. Psychostimulant-induced hyperlocomotion has been proposed as an animal model for the study of antimanic drugs. The present
Lithium's effects on muscarinic receptor binding parameters: a relationship to therapeutic efficacy?
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Variables confounding efforts to interpret data on lithium's effects in laboratory animals in vivo and from in vitro muscarinic receptor binding studies are discussed. After accounting for the effects of these variables, the author concludes that it is of theoretical interest and heuristic value to
Clinical comparison of extended-release divalproex versus delayed-release divalproex: pooled data analyses from nine trials.
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Divalproex sodium is an effective anticonvulsant, antimanic, and migraine prophylaxis agent. Recently, a new extended-release (ER) formulation of divalproex sodium has become available, which allows for once-daily dosing and provides prolonged therapeutic serum levels. Using data pooled from nine
In vivo pharmacological effects of JZP-4, a novel anticonvulsant, in models for anticonvulsant, antimania and antidepressant activity.
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JZP-4 is a potent calcium and sodium channel blocker, which is currently being evaluated in patients as an anticonvulsant and mood stabilizer. In the current studies, JZP-4 was evaluated in a variety of animal models for anticonvulsant, antimania and antidepressant activity. In the mouse and rat
[A trial of clonazepam treatment for manic-depressive psychoses].
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Clonazepam, which is a benzodiazepine structurally related to chlordiazepoxide hydrochloride, diazepam and nitrazepam, has been available for the treatment of seizure disorders in the USA since 1976 and in Japan since 1981. Recently, clonazepam has attracted interest as drug for the treatment of
Electroconvulsive therapy of acute manic episodes: a review of 50 years' experience.
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OBJECTIVE
The most common indication for electroconvulsive therapy (ECT) is major depression. It is less recognized that ECT is effective also in the treatment of acute mania. This article aims to provide a comprehensive and critical review of the literature on the use of ECT for manic
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