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Cumulative reduction of primary skin tumor growth in UV-irradiated mice by the combination of retinyl palmitate and canthaxanthin.

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The effects of dietary supplementation with retinyl palmitate, canthaxanthin, or the combination of both, on photocarcinogenesis was determined in pigmented C3H/HeN mice. The basal diet was the American Institute of Nutrition Diet 76A, to which was added 120 IU of retinyl palmitate per g diet, 1%

Effect of beta-carotene and canthaxanthin on tert-butyl hydroperoxide-induced lipid peroxidation in murine normal and tumor thymocytes.

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It has been reported that the anticarcinogenic effect of carotenoids could be related to an antioxidant mechanism. The antioxidant efficiency of beta-carotene and canthaxanthin was evaluated in murine normal and tumor thymocytes. Normal and tumor cells were exposed under air to tert-butyl

Enhanced resistance to an antigenic tumor in immunosuppressed mice by dietary retinyl palmitate plus canthaxanthin.

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Retinoids and certain carotenoids, e.g., beta-carotene and canthaxanthin, have been found to prevent photocarcinogenesis in mice and also to act as immunoenhancers. The hypothesis that retinoids and carotenoids inhibit photocarcinogenesis by preventing UV induction of immunosuppression predicts that

Regression of experimental hamster cancer by beta carotene and algae extracts.

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The effect of algae extract on tumor regression was studied. Phycotene (extract of Spirulina and Dunaliella algae) 250 micrograms in 0.1 ml MEM (minimum essential medium) was injected locally into DMBA (7, 12 dimethylbenz(a)anthracene)-induced squamous cell carcinomas of hamster buccal pouch in 20

Liarozole amplifies retinoid-induced apoptosis in human prostate cancer cells.

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Beta-carotene, canthaxanthin and retinoic acid (RA) inhibited growth of human DU145 prostate cancer cells by 45, 56 and 18%, respectively. Lycopene was also found to inhibit cell growth. Other carotenoids including xanthophyll (lutein), cryptoxanthin and zeaxanthin were less effective. Liarozole (a

Carotenoids and cancer in animal models.

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As evidence accumulated from epidemiological studies that beta-carotene acts as a chemopreventive agent with respect to inhibiting the appearance of certain types of tumors in humans, attention focused on animal models as a means of extending our understanding of carotenoid function. Unfortunately,

Serum antioxidants and subsequent mortality rates of all causes or cancer among rural Japanese inhabitants.

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The purpose of this study was to investigate whether a relationship exists between mortality rates and serum antioxidant levels among Japanese inhabitants. The follow-up subjects, who participated in comprehensive health examinations, consisted of 2444 inhabitants (949 males and 1495 females) of a

The selective cytotoxic effect of carotenoids and alpha-tocopherol on human cancer cell lines in vitro.

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This study compares the toxic effects of the carotenoids, beta-carotene and canthaxanthin, and alpha-tocopherol (vitamin E) on human tumor cells and their normal counterparts in vitro. Seven different malignant cell lines were examined: oral carcinoma (two cell lines), breast (two cell lines), lung

Carotenoid analysis of several dark-green leafy vegetables associated with a lower risk of cancers.

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We have examined the carotenoid contents of several dark green vegetables found to be associated with a lower risk of various epithelial cancers in our epidemiological study and animal study. Samples of these vegetables were quantitatively examined by high-performance liquid chromatography (HPLC) on

Effects of Dietary Xanthophylls, Canthaxanthin and Astaxanthin on N-Methyl-N-nitrosourea-induced Rat Mammary Carcinogenesis.

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BACKGROUND Natural xanthophylls, canthaxanthin and astaxanthin are known to exhibit anticancer activity. However, the dietary effects of canthaxanthin and astaxanthin on N-methyl-N-nitrosourea (MNU)-induced mammary cancer remain controversial, and their mechanisms of action have not been clearly

Dietary carotenoids inhibit neoplastic transformation and modulate gene expression in mouse and human cells.

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Many epidemiologic studies have associated the consumption of diets rich in fruit and green and yellow vegetables with a decreased risk of cancer. Of the many components of such a diet, the content of carotenoids, particularly beta-carotene, has been most consistently linked to decreased risk. The

Carotenoids in cancer chemoprevention and therapeutic interventions.

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Carotenoid (CARs: beta-carotene BC and/or canthaxanthin CX) supplementation have been shown to be chemopreventive in animals, since 1980, against direct or indirect chemical carcinogenesis/photo-carcinogenesis of the skin, breast, stomach, salivary glands, colon-rectum, urinary bladder, and against

An international evaluation of the cancer preventive potential of carotenoids.

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The IARC convened a Working Group of experts in December 1997 to evaluate the cancer-preventive potential of carotenoids and to compile the second volume of the IARC Handbooks of Cancer Prevention. In observational epidemiological studies, beta-carotene is associated with reduced risks for cancer at

Antitumor effect of an oral administration of canthaxanthin on BALB/c mice bearing thymoma cells.

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The antitumor effect of canthaxanthin in BALB/c mice bearing a transplantable thymoma was investigated. Male or female mice received two different doses of canthaxanthin (7 or 14 micrograms/g body wt/day) starting 15 days before tumor inoculation (7 x 10(7) cells i.p.). Canthaxanthin treatment

Antitumor activity of beta-carotene, canthaxanthin and phytoene.

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Mice were given either beta-carotene or either of two carotenoids with no vitamin A activity--canthaxanthin or phytoene--or placebo. Skin tumors were induced in each group by each of three methods: (1) UV-B (290--320 nm); (2) dimethylbenz(a)anthracene (DMBA)/croton oil applications; (3) DMBA

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