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geranium sanguineum/polyphenol

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Biologically active constituents of a polyphenol extract from Geranium sanguineum L. with anti-influenza activity.

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From the aerial roots of the medicinal plant Geranium sanguineum L. a polyphenol-rich extract with strong anti-influenza activity has been isolated. To investigate its active fractions, the extract was partitioned by solvents with increasing polarity. The n-BuOH fraction contained the majority of

Influenza virus variants with reduced susceptibility to inhibition by a polyphenol extract from Geranium sanguineum L.

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A polyphenol extract obtained from the Bulgarian medicinal plant Geranium sanguineum L. (PC) inhibited influenza virus reproduction in vitro, in ovo and in vivo. The inhibitory activity of the plant preparation was proved to be selective and specific. Two variants of the virus A/chicken/Germany/34,

In vitro antioxidant activity of polyphenol extracts with antiviral properties from Geranium sanguineum L.

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Recent evidence shows that plant polyphenols exhibit antioxidant and radical scavenging properties. By three separate and complementary methods--DPPH assay, beta-carotene-linoleic acid assay and NBT-reduction assay it was established that a polyphenol-rich extract from the medicinal plant Geranium

Antioxidant and prooxidant properties of a polyphenol-rich extract from Geranium sanguineum L. in vitro and in vivo.

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A polyphenol-rich extract from Geranium sanguineum L. (PC) protected biological membranes due to its antioxidant capacity. PC caused a dose-dependent decrease of the osmotic hemolysis of human erythrocytes and increased their resistance against the toxic effect of H(2)O(2); no effect on catalase

[Antiviral action of a polyphenol complex isolated from the medicinal plant Geranium sanguineum L. II. Its inactivating action on the influenza virus].

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[Antiviral action of a polyphenol complex isolated from the medicinal plant Geranium sanguineum L. I. Its inhibiting action on the reproduction of the influenza virus].

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[The antiviral action of a polyphenol complex isolated from the medicinal plant Geranium sanguineum L. VI. Reproduction of the influenza virus pretreated with the polyphenol complex].

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[Combined action of antiviral substances of natural and synthetic origin. I. The anti-influenza action of a combination of the polyphenol complex isolated from Geranium sanguineum L. and remantadine in vitro and in ovo].

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Protective efficacy of an aerosol preparation, obtained from Geranium sanguineum L., in experimental influenza infection.

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A polyphenol-rich extract from the aerial roots of the medicinal plant Geranium sanguineum L. (PC) protected mice from mortality in the experimental influenza A/Aichi/2/68 (H3N2) virus infection. To provide evidence how a maximum therapeutic benefit can be derived of this preparation, it was

Antiinfective activity of a plant preparation from Geranium sanguineum L.

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A methanol extract (PC) has been obtained from the Bulgarian medicinal plant Geranium sanguineum L. The antiinfective activity of the plant preparation was studied. The extract inhibited the reproduction of a range of viruses (influenza, herpes simplex, vaccinia, HIV-I) in cell cultures. Its

A fungal Cu/Zn-containing superoxide dismutase enhances the therapeutic efficacy of a plant polyphenol extract in experimental influenza virus infection.

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The combined protective effect of a polyphenol-rich extract, isolated from Geranium sanguineum L. (PC), and a novel naturally glycosylated Cu/Zn-containing superoxide dismutase, produced from the fungal strain Humicula lutea 103 (HL-SOD), in the experimental influenza A virus infection (EIVI) in

Effect of a plant polyphenol-rich extract on the lung protease activities of influenza-virus-infected mice.

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Influenza infection was induced in white mice by intranasal inoculation of the virus A/Aichi/2/68 (H3N2). The lung protease and the protease-inhibitory activities were followed for 9 days after infection. The intranasal application of a polyphenol-rich extract (PC) isolated from Geranium sanguineum

A plant polyphenol-rich extract restores the suppressed functions of phagocytes in influenza virus-infected mice.

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Influenza infection was induced in white ICR mice by intranasal (i.n.) inoculation of the virus A/Aichi/2/68 (H3N2). The number, migration and phagocyte indices of alveolar and peritoneal macrophages (pMØ) and of blood polymorphonuclear leukocytes (PMNs), as well as the inhibition of the PMN

Antiherpes virus activity of extracts from the medicinal plant Geranium sanguineum L.

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The herpes virus inhibitory effect of five extracts from the Bulgarian medicinal plant Geranium sanguineum L. (Geraniaceae) was investigated. The water extract (WE) from the aerial roots of the plant was the least toxic for cell cultures and inhibited significantly the replication of herpes simplex

Synergistic inhibition of influenza A virus replication by a plant polyphenol-rich extract and epsilon-aminocaproic acid in vitro and in vivo.

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A combined antiviral effect of a polyphenol-rich extract of the medicinal plant Geranium sanguineum L. (PC) and a protease inhibitor, epsilon-aminocaproic acid (ACA) was examined in Influenza A virus (IAV)-infected MDCK cell cultures and mice. Synergistic, antagonistic, or indifferent antiviral
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