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pyrazine/възпаление
Линкът е запазен в клипборда
Страница 1 от 63 резултата
Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases
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Вход / Регистрация
FIELD OF THE INVENTION
The present invention relates to a class of fused pyrazine compounds capable of binding to the active site of a serine/threonine kinase, the expression of which is involved in the pathway resulting in the degradation of extra-cellular matrix (ECM), joint degeneration and
Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases
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FIELD OF THE INVENTION
The present invention relates to a class of fused pyrazine compounds capable of binding to the active site of a serine/threonine kinase, the expression of which is involved in the pathway resulting in the degradation of extra-cellular matrix (ECM), joint degeneration and
Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases
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Вход / Регистрация
FIELD OF THE INVENTION
The present invention relates to a class of fused pyrazine compounds capable of binding to the active site of a serine/threonine kinase, the expression of which is involved in the pathway resulting in the degradation of extra-cellular matrix (ECM), joint degeneration and
Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases
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FIELD OF THE INVENTION
The present invention relates to a class of fused pyrazine compounds capable of binding to the active site of a serine/threonine kinase, the expression of which is involved in the pathway resulting in the degradation of extra-cellular matrix (ECM), joint degeneration and
Substituted benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses
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FIELD OF THE INVENTION
This invention relates to biologically active chemical compounds, namely benzoimidazolyl-pyrazine derivatives and structurally related compounds that are used for immunosuppression or to treat or prevent inflammatory conditions, allergic disorders and immune
Benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses
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STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
Not applicable.
THE NAMES OF THE PARTIES TO A JOINT RESEARCH AGREEMENT
Not applicable.
INCORPORATION-BY-REFERENCE OF MATERIAL SUBMITTED ON A COMPACT DISC
Not applicable.
BACKGROUND OF THE INVENTION
(1) Field of the Invention
This
Benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses
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Вход / Регистрация
FIELD OF THE INVENTION
This invention relates to biologically active chemical compounds, namely benzoimidazolyl-pyrazine derivatives and structurally related compounds that are used for immunosuppression or to treat or prevent inflammatory conditions, allergic disorders and immune
2-amido pyrazines for inflammation and immune related uses
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FIELD OF THE INVENTION
This invention relates to biologically active chemical compounds, namely pyrazinyl, pyrimidinyl and pyridazinyl derivatives that may be used for immunosuppression or to treat or prevent inflammatory conditions, allergic disorders and immune disorders.
BACKGROUND OF THE
Substituted imidazo[1,2-a]pyrazines as TNF activity modulators
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CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a US national phase of International Application No. PCT/EP2013/064332 filed on Jul. 5, 2013, which claims priority to Great Britain Patent Application No. 1212513.4 filed on Jul. 13, 2012.
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH
Pyrrolo[2,3-B]pyrazines as SYK inhibitors
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Protein kinases constitute one of the largest families of human enzymes and regulate many different signaling processes by adding phosphate groups to proteins; particularly tyrosine kinases phosphorylate proteins on the alcohol moiety of tyrosine residues. The tyrosine kinase family includes members
Pyrazine compounds and uses as PI3K inhibitors
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FIELD OF THE INVENTION
This present invention is related to the use of pyrazine derivatives of Formula (I) for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, allergy, asthma,
Pyrazine derivatives and use as PI3K inhibitors
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FIELD OF THE INVENTION
This present invention is related to the use of pyrazine derivatives of Formula (I) for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, allergy, is
Fused tricyclic imidazo pyrazines as modulators of TNF activity
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This application is a U.S. national phase application under 35 USC 371 of International Patent Application no. PCT/EP2016/062898, filed Jun. 7, 2016, which claims the benefit of Great Britain Application no. 1509888.2, filed Jun. 8, 2015.
The present invention relates to a class of fused imidazole
8-methyl-1-phenyl-imidazol[1,5-a]pyrazine compounds as Lck inhibitors and uses thereof
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BACKGROUND OF THE INVENTION
Non-receptor tyrosine kinases are intracellular enzymes which, in the presence of ATP phosphorylate proteins at tyrosine residues. These enzymes are key regulators of cellular signal transduction, leading to the activation, proliferation and differentiation of cells. The
Substituted pyrazino[2,3-b]pyrazines as mTOR kinase inhibitors
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2. BACKGROUND
Provided herein are certain heteroaryl compounds, compositions comprising an effective amount of one or more such compounds and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by
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