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thiophene/възпаление
Линкът е запазен в клипборда
Страница 1 от 61 резултата
Anti-inflammatory and analgesig thiophene acetic acid derivatives, compositions, and method of use therefor
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Вход / Регистрация
Related compounds are described in French patent No. 2,346,348 and Chem. Abs., Vol. 95 No. 7 (1981) p. 689, No. 61895d.
OBJECTS OF THE INVENTION
It is an object of the invention to provide the novel compounds of formula I and their salts and a novel process and intermediates for their
Anti-inflammatory and analgesic 3-hydroxybenzo[b]thiophene derivatives, compositions, and method of use therefor
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BACKGROUND OF THE INVENTION
This invention relates to benzothiophenes, particularly 3-hydroxybenzothiophenes, having the 2-carbon side chains, for example, 3-acetoxy-2-butyl-5-chloro-benzo[b]thiophene and its 2-benzyl analog.
These novel benzothiophenes are found to be either specific 5-lipoxygenase
Cyclopenta[b]thiophenes having anti-inflammatory activity similar to steroids
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Inflammation is a response of mammals to a variety of stimuli including trauma and exposure to temperature extremes as well as disturbances of the immune system resulting in diseases such as rheumatoid arthritis. Modification of the inflammatory response in the treatment of various diseases often
Thiophene compounds for inflammation and immune-related uses
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RELATED APPLICATION
This application claims the benefit of U.S. provisional application No. 60/646,772, filed on Jan. 25, 2005, the entire teachings of which are incorporated herein by reference.
FIELD OF THE INVENTION
This invention relates to biologically active chemical compounds, namely
Novel thiophene-acetic acids
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OBJECTS OF THE INVENTION
It is an object of the invention to provide the novel thiophene acetic acid derivatives of formulae I and II.
It is another object of the invention to provide a novel process for the preparation of the thiophene acetic acid derivatives of formulae I and II.
It is an
Novel salt of 5-(benzoyl)-thiophene-2-.alpha.-methyl-acetic acid
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STATE OF THE ART
Copending, commonly assigned application Ser. No. 610,110 filed Sept. 4, 1975 describes various thiophene-acetic acids and various salts thereof including 5-(benzoyl)-thiophene-2-.alpha.-methyl-acetic acid having analgesic and anti-inflammatory activity but the said acid and its
Derivatives of 3-hydroxyazabenzo(beta)thiophene useful as 5-lipoxygenase inhibitors
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BACKGROUND OF THE INVENTION
This invention relates to 3-hydroxyazabenzothiophenes having the 2-position substituted with an optionally substituted aryl, aralkyl, alkyl, or alkenyl group, for example, 3-acetyloxy-7-aza-2-phenyl-benzo[b]thiophene.
These novel azabenzothiophenes are found to be either
Derivatives of 3-hydroxyazabenzo(B)thiophene useful as 5-lipoxygenase inhibitors
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BACKGROUND OF THE INVENTION
This invention relates to 3-hydroxyazabenzothiophenes having the 2-position substituted with an optionally substituted aryl, aralkyl, alkyl, or alkenyl group, for example, 3-acetyloxy-7-aza-2-phenyl-benzo[b]thiophene.
These novel azabenzothiophenes are found to be either
Derivatives of 3-hydroxyazabenzo[b]thiophene useful as 5-lipoxygenase inhibitors
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BACKGROUND OF THE INVENTION
This invention relates to 3-hydroxyazabenzothiophenes having the 2-position substituted with an optionally substituted aryl, aralkyl, alkyl, or alkenyl group, for example, 3-acetyloxy-7-aza-2-phenyl-benzo[b]thiophene.
These novel azabenzothiophenes are found to be either
Thiophene nitrone compounds
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to novel thiophene nitrone compounds and their use as therapeutic agents and analytical reagents. More particularly, this invention concerns novel thiophene nitrone compounds and their use as therapeutics for treating
Thiophenes and uses thereof
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BACKGROUND OF THE INVENTION
Phosphatidylinositol 3-kinase (PI3K) is a family of lipid kinases that phosphorylate phosphatidylinositol at the 3' position of the inositol ring. PI3K is comprised of several classes of genes, including Class IA, IB, II and III and some of these classes contain several
Thiophene-2-carboxamidotetrazoles and pharmaceutical use thereof
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BACKGROUND OF THE INVENTION
This invention relates thiophene-2-carboxamidotetrazoles which inhibit the effects of the Mac-1 leukocyte molecule, and as such are useful for treating diseases mediated thereby, including inflammatory disorders.
Leukocyte-endothelial interactions are involved in the
Tricyclic fused thiophene derivatives as JAK inhibitors
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TECHNICAL FIELD
The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory
Tricyclic fused thiophene derivatives as JAK inhibitors
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TECHNICAL FIELD
The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory
Tricyclic fused thiophene derivatives as JAK inhibitors
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TECHNICAL FIELD
The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory
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