Green Tea Anticancer Mechanisms in Smokers
কীওয়ার্ডস
বিমূর্ত
বর্ণনা
Green tea contains phytochemicals, especially flavonoids. Phytochemicals are not absolutely required for normal functions, but may confer health benefits such as antioxidant actions. One can live without phytochemicals, but one may live longer and better with them. The phytochemicals in tea have been proposed to inhibit cancer onset via several different mechanisms. An obvious question is: Can anti-cancer actions of green tea be duplicated by black tea, which in the USA, is consumed more than green tea? The question remains unanswered, and will not be addressed by this project since many questions about green tea have not been answered yet. The contents of both type teas overlap in flavonoids, but green tea has more of the agents thought to be most effective. For example, some of the research cited below uses the flavonoid epigallocatechin gallate. Green tea has 5 times more of this flavonoid than black tea.
This study has two purposes. First, a case will be made that green tea may have several anti-cancer mechanisms, but this contention is not well confirmed by human intervention studies. This case will be made by addressing four questions. Second, justification will be given for the choice of mechanisms to be examined in this project's human intervention.
তারিখ
| সর্বশেষ যাচাই করা হয়েছে: | 03/31/2015 |
| প্রথম জমা দেওয়া: | 06/22/2010 |
| আনুমানিক তালিকাভুক্তি জমা দেওয়া হয়েছে: | 07/12/2010 |
| প্রথম পোস্ট: | 07/13/2010 |
| সর্বশেষ আপডেট জমা দেওয়া হয়েছে: | 04/19/2015 |
| সর্বশেষ আপডেট পোস্ট: | 04/20/2015 |
| আসল অধ্যয়ন শুরুর তারিখ: | 05/31/2010 |
| আনুমানিক প্রাথমিক সমাপ্তির তারিখ: | 07/31/2013 |
| আনুমানিক অধ্যয়ন সমাপ্তির তারিখ: | 07/31/2013 |
অবস্থা বা রোগ
হস্তক্ষেপ / চিকিত্সা
Dietary Supplement: Green Tea
Other: No Green Tea
পর্যায়
বাহু গ্রুপ
| বাহু | হস্তক্ষেপ / চিকিত্সা |
|---|---|
| Experimental: Green Tea 4 cups daily of green tea for 6 weeks | Dietary Supplement: Green Tea Green Tea 4 cups daily |
| Placebo Comparator: No Green Tea 4 cups daily of placebo tea for 6 weeks | Other: No Green Tea 4 cups placebo tea for 6 weeks |
যোগ্যতার মানদণ্ড
| বয়স অধ্যয়নের জন্য যোগ্য | 23 Years প্রতি 23 Years |
| লিঙ্গ অধ্যয়নের জন্য যোগ্য | All |
| স্বাস্থ্যকর স্বেচ্ছাসেবীদের গ্রহণ করে | হ্যাঁ |
| নির্ণায়ক | Inclusion Criteria: - Healthy 23-40 year old males and non-pregnant females, who are moderately heavy smokers (1-1.75 packs/day, > 2 years) Exclusion Criteria: - Habitual tea intake - Habitual flavonoid supplementation - Soy product intake over twice a week (soy is high in flavonoids). - Pulmonary diseases - Chronic or acute infection - Admission of heavy alcohol intake (> 14 beers or drinks a week) - Body mass index (BMI) > 30 (moderately overweight subjects will be taken) - Abnormal EKG - History of heart or other major health problems (ie arthritis, diabetes). - Subjects with slightly high blood pressure will be eligible for the project, but more severe hypertension (>150/100) |
ফলাফল
প্রাথমিক ফলাফল ব্যবস্থা
1. Antioxidant effects of green tea versus placebo consumption. [Measured at post treatment]
মাধ্যমিক ফলাফলের ব্যবস্থা
1. Non-antioxidant, cancer-relevant effects of green tea consumption [Measured at pre-treatment and post treatment]
