Spatial Repellents for Arbovirus Control
কীওয়ার্ডস
বিমূর্ত
বর্ণনা
Protection provided by this product will be measured using entomological and virological approaches, comparing entomological indices will be measured through standard household monitoring of Aedes aegypti population densities, while DCZV transmission will be measured through door-to-door surveillance for active dengue disease and through serological monitoring for DCZV exposure in a randomized cluster trial.
The investigators will establish a cohort of 3,400 persons, primarily children 2-12 years of age and adults who have not been previously infected with DCZV who will provide annual blood samples when they are healthy (longitudinal cohort), whereas in the same clusters the investigators expect to monitor up to 27,500 residents for active dengue disease (febrile surveillance cohort). The cohort will be monitored for a period of 2 years. The use of spatial repellents has never been tested on a large scale to reduce disease and could change vector control practices worldwide, reducing the amount of chemical insecticides applied and also prevent the development of insecticide resistance. The investigators plan to implement a short questionnaire to determine levels of acceptability and perceived efficacy amongst participating households.
The project will be carried out in the Amazonia City of Iquitos, Peru, which has a well-established infrastructure for studying urban dengue fever. The study will generate rigorous evidence, documenting and evaluating the impact of SR products on human infection rates, to be considered and used by academia, industry and public health key stakeholders at the global, regional, national and/or local level and drive efforts to acquire full recommendation of SR products for inclusion in disease control programs.
তারিখ
| সর্বশেষ যাচাই করা হয়েছে: | 01/31/2019 |
| প্রথম জমা দেওয়া: | 01/22/2018 |
| আনুমানিক তালিকাভুক্তি জমা দেওয়া হয়েছে: | 06/10/2018 |
| প্রথম পোস্ট: | 06/11/2018 |
| সর্বশেষ আপডেট জমা দেওয়া হয়েছে: | 02/14/2019 |
| সর্বশেষ আপডেট পোস্ট: | 02/17/2019 |
| আসল অধ্যয়ন শুরুর তারিখ: | 05/31/2015 |
| আনুমানিক প্রাথমিক সমাপ্তির তারিখ: | 12/31/2018 |
| আনুমানিক অধ্যয়ন সমাপ্তির তারিখ: | 12/31/2018 |
অবস্থা বা রোগ
হস্তক্ষেপ / চিকিত্সা
Other: Transfluthrin
Other: Placebo
পর্যায়
বাহু গ্রুপ
| বাহু | হস্তক্ষেপ / চিকিত্সা |
|---|---|
| Experimental: Transfluthrin transfluthrin | Other: Transfluthrin passive emanator with formulated transfluthrin |
| Placebo Comparator: Placebo inert ingredients | Other: Placebo passive emanator with formulated inert ingredients |
যোগ্যতার মানদণ্ড
| বয়স অধ্যয়নের জন্য যোগ্য | 2 Years প্রতি 2 Years |
| লিঙ্গ অধ্যয়নের জন্য যোগ্য | All |
| স্বাস্থ্যকর স্বেচ্ছাসেবীদের গ্রহণ করে | হ্যাঁ |
| নির্ণায়ক | LONGITUDINAL SEROCONVERSION Individual Level Inclusion Criteria: - ≥ 2 years of age - plans to stay in study area for minimum of 12 months - resident of household or frequent visitor (~20% of day hours in house/mo) Exclusion Criteria: - < 2 years of age - temporary visitor to household - plans to leave study area within next 12 months FEBRILE SURVEILLANCE Household Level Inclusion Criteria: - adult head of households agree to health visits and census - individuals spend a minimum of 4hrs per week during the daytime hours or sleep in the house. Temporary residents can be included. Exclusion Criteria: - households where study personnel identify a security risk (i.e., site where drugs are sold, residents are always drunk or hostile) - sites where no residents spend time during the day (i.e., work 7d a week outside the home) FEBRILE SURVEILLANCE Individual Level Inclusion Criteria: - individual who spends a minimum of 4 hours per week within the household - ≥ 2 years of age - fever at the time of presentation or report of feverishness within the previous 24 hours or presenting with a rash, arthralgia, arthritis or non-purulent conjunctivitis (suspicion of Zika determined by project physician) Exclusion Criteria: - <2 years of age - individuals who have spent less than 4 hours in the household during the week prior to illness ENTOMOLOGICAL MONITORING Household Level Inclusion Criteria: * adult head of households agrees to survey Exclusion Criteria: * properties where study personnel identify a security risk (i.e., site where drugs are sold, residents are always drunk or hostile) SPATIAL REPELLENT INTERVENTION Household Level Inclusion Criteria: * adult head of households agrees to intervention deployment and to provide access to team member at 2-3 week intervals to change product Exclusion Criteria: * properties where study personnel identify a security risk (i.e., site where drugs are sold, residents are always drunk or hostile) |
ফলাফল
প্রাথমিক ফলাফল ব্যবস্থা
1. Incidence of DCZV infections [2 years]
মাধ্যমিক ফলাফলের ব্যবস্থা
1. Aedes spp. pupal density [2 years]
2. Aedes spp. adult density [2 years]
3. Aedes spp. female blood fed density [2 years]
4. Aedes spp. female parous density [2 years]
5. Perception of product efficacy [2 years]
