Tart Cherry Supplementation and Women's Bone Health Study
কীওয়ার্ডস
বিমূর্ত
বর্ণনা
Tart cherries are an excellent course of phenolic compounds and anthocyanins, and in pre-clinical studies have been shown to prevent age-related bone loss. Based on these findings, this pilot study was designed to investigate the effects of three months of tart cherry juice supplementation on improving markers of oxidative stress and bone metabolism in older women. Women (n=30), aged 65-80 yrs, will be recruited for the study and randomly assigned to one of two doses of tart cherry juice (8 or 16 fl oz) per day prepared from a Montmorency cherry concentrate (King Orchards, Central Lake, MI). Study participants will complete two study visits to the Nutritional Sciences Clinical Research Center. At the first visit, informed consent will be obtained and relevant medical history and anthropometric measures will be taken by the research team. A blood draw will be performed to assess baseline, biochemical markers of bone metabolism and inflammation as well as indicators of oxidative status. A physical activity and food frequency questionnaire will be completed by each study participant. Whole body, hip and spine bone density (DXA) scan will be performed by certified bone densitometrist. A 3-month final visit will be scheduled for all study participants in which most of the procedures described at baseline (except DXA) will be repeated. Change in primary and secondary outcome measures (i.e., bone, inflammation and oxidative stress biomarkers) will be assessed.
তারিখ
| সর্বশেষ যাচাই করা হয়েছে: | 10/31/2019 |
| প্রথম জমা দেওয়া: | 11/09/2019 |
| আনুমানিক তালিকাভুক্তি জমা দেওয়া হয়েছে: | 11/14/2019 |
| প্রথম পোস্ট: | 11/17/2019 |
| সর্বশেষ আপডেট জমা দেওয়া হয়েছে: | 11/14/2019 |
| সর্বশেষ আপডেট পোস্ট: | 11/17/2019 |
| আসল অধ্যয়ন শুরুর তারিখ: | 06/05/2017 |
| আনুমানিক প্রাথমিক সমাপ্তির তারিখ: | 05/30/2018 |
| আনুমানিক অধ্যয়ন সমাপ্তির তারিখ: | 05/30/2018 |
অবস্থা বা রোগ
হস্তক্ষেপ / চিকিত্সা
Dietary Supplement: tart cherry juice concentrate is a commercial product provided by King Orchards (Central Lake, MI)
পর্যায়
বাহু গ্রুপ
| বাহু | হস্তক্ষেপ / চিকিত্সা |
|---|---|
| Active Comparator: Dose 1 Participants consume 8 fl oz of tart cherry juice per day. | |
| Experimental: Dose 2 Participants consume 2 x 8 fl oz of tart cherry juice per day. |
যোগ্যতার মানদণ্ড
| বয়স অধ্যয়নের জন্য যোগ্য | 65 Years প্রতি 65 Years |
| লিঙ্গ অধ্যয়নের জন্য যোগ্য | Female |
| স্বাস্থ্যকর স্বেচ্ছাসেবীদের গ্রহণ করে | হ্যাঁ |
| নির্ণায়ক | Inclusion Criteria: - Women, 65-80 years of age - Capacity to give informed consent Exclusion Criteria: - Hormone replacement therapy in the 3 months prior to starting the study - Bisphosphonates in the 3 months prior to starting the study - Raloxifene in the 3 months prior to starting the study - Intermittent parathyroid hormone in the 3 months prior to starting the study - Growth hormone or steroids in the 3 months prior to starting the study - Osteoporosis - Renal disease - Cancer - Cardiovascular disease - Diabetes - Respiratory disease - Gastrointestinal diseases - Liver disease - Other chronic conditions that could affect bone metabolism |
ফলাফল
প্রাথমিক ফলাফল ব্যবস্থা
1. Bone-specific alkaline phosphatase (U/L) [Change from baseline to final visits (3 month intervention)]
2. Tartrate resistant acid phosphatase (U/L) [Change from baseline to final visits (3 month intervention)]
মাধ্যমিক ফলাফলের ব্যবস্থা
1. C-reactive protein (mg/L) [Change from baseline to final visits (3 month intervention)]
2. Thiobarbituric acid reactive species (TBARS) (U/L) [Change from baseline to final visits (3 month intervention)]
