Allicin Bioavailability From Garlic Supplements and Garlic Foods
কীওয়ার্ডস
বিমূর্ত
বর্ণনা
The bioavailability of allicin, the main active compound of garlic, from garlic supplements and garlic foods is highly questionable and unpredictable from in vitro tests, due to dependence upon alliinase activity under conditions that challenge alliinase activity (heat, gastric acid, intestinal proteases). It is likely that garlic supplement manufacturing procedures and coatings, meal conditions when supplements are consumed (high or low protein), and garlic food preparation conditions (temperature, surface area) will greatly affect allicin bioavailability. Such variability may account for some of the many conflicts seen in clinical trials on cardiovascular disease risk factors.
To resolve these issues, this study will determine the actual bioavailability of allicin from several types of garlic supplements and garlic foods under various conditions. Bioavailability will be determined by measuring the area under the 32-hour curve for breath concentrations of allyl methyl sulfide, the main metabolite allicin.
তারিখ
| সর্বশেষ যাচাই করা হয়েছে: | 10/31/2009 |
| প্রথম জমা দেওয়া: | 03/31/2009 |
| আনুমানিক তালিকাভুক্তি জমা দেওয়া হয়েছে: | 03/31/2009 |
| প্রথম পোস্ট: | 04/01/2009 |
| সর্বশেষ আপডেট জমা দেওয়া হয়েছে: | 11/17/2009 |
| সর্বশেষ আপডেট পোস্ট: | 11/19/2009 |
| আসল অধ্যয়ন শুরুর তারিখ: | 03/31/2009 |
| আনুমানিক প্রাথমিক সমাপ্তির তারিখ: | 03/31/2011 |
| আনুমানিক অধ্যয়ন সমাপ্তির তারিখ: | 03/31/2011 |
অবস্থা বা রোগ
হস্তক্ষেপ / চিকিত্সা
Other: 1
Dietary Supplement: 2
পর্যায়
বাহু গ্রুপ
| বাহু | হস্তক্ষেপ / চিকিত্সা |
|---|---|
| Active Comparator: 1 Positive control with 100% allicin bioavailability | Other: 1 1 gram crushed garlic in gelatin capsules, one dose once every 2-16 weeks |
| Experimental: 2 garlic powder tablet | Dietary Supplement: 2 tablets, dose to contain 1 gram of garlic powder, consume one dose once every two weeks for up to 52 weeks |
যোগ্যতার মানদণ্ড
| বয়স অধ্যয়নের জন্য যোগ্য | 18 Years প্রতি 18 Years |
| লিঙ্গ অধ্যয়নের জন্য যোগ্য | All |
| স্বাস্থ্যকর স্বেচ্ছাসেবীদের গ্রহণ করে | হ্যাঁ |
| নির্ণায়ক | Inclusion Criteria: - in good health (self-judged) - BMI (body mass index): 19-32 kg/m2 - not planning to move out of the area in the next year - willing to abstain from consuming garlic and onion and foods that contain them for two days prior to and during each test (diet restrictions) - able to deliver bags of breath to the research facility five times in two days - willing to eat whole wheat tuna sandwiches Exclusion Criteria: - known serious health problems: diabetes, heart disease, active neoplasms, renal or liver disease, hyper- or hypothyroidism, breathing disorders, gastroesophageal reflux disease (GERD), gastrointestinal disease (absorption interference) - known allergy to garlic or wheat - tobacco user - excessive alcohol intake (³2 drinks/day, self-reported) - unable to speak English well |
ফলাফল
প্রাথমিক ফলাফল ব্যবস্থা
1. Breath allyl methyl sulfide [1-32 hours]
