Comparison of Myoinositol and Metformin in PCO
কীওয়ার্ডস
বিমূর্ত
বর্ণনা
PCOS is a common endocrine disorder in women of reproductive age associated with insulin resistance. Metformin and Myo-inositol being insulin sensitizers improve biochemical parameters. it is aimed to compare the effect of myoinositol and metformin in the resumption of the spontaneous menstrual cycle in patients diagnosed with PCOS or having oligo/amenorrhea, reduction in weight and BMI, Improvement in the biochemical and clinical profile of patients with the polycystic syndrome.
Inclusion criteria: will be based on the Rotterdam criteria of diagnosing PCO. Patients presenting with a history of secondary amenorrhea, irregular menstrual cycle, oligomenorrhea, weight gain, hirsutism, and already diagnosed cases of PCO will be included in this group.
Patients with history of Hyperprolactinemia, Cushing's disease, Hypothyroidism/ Hyperthyroidism, Pregnancy and nursing, Established type 1 or type 2 diabetes mellitus, Any history of drug intake e.g. anti-diabetic or estrogen and progesterone, History of treatment for the same complaint taken in the last 3 months, Unable to come for regular follow-ups, Any pathological cause of bleeding e.g. Fibroid, Polyp, Cervical pathology and known allergic to these drugs would be excluded.
তারিখ
| সর্বশেষ যাচাই করা হয়েছে: | 11/30/2019 |
| প্রথম জমা দেওয়া: | 10/21/2019 |
| আনুমানিক তালিকাভুক্তি জমা দেওয়া হয়েছে: | 12/16/2019 |
| প্রথম পোস্ট: | 12/17/2019 |
| সর্বশেষ আপডেট জমা দেওয়া হয়েছে: | 12/16/2019 |
| সর্বশেষ আপডেট পোস্ট: | 12/18/2019 |
| আসল অধ্যয়ন শুরুর তারিখ: | 12/31/2019 |
| আনুমানিক প্রাথমিক সমাপ্তির তারিখ: | 12/30/2020 |
| আনুমানিক অধ্যয়ন সমাপ্তির তারিখ: | 02/24/2021 |
অবস্থা বা রোগ
হস্তক্ষেপ / চিকিত্সা
Drug: Metformin Hydrochloride
Drug: Myo-inositol
পর্যায়
বাহু গ্রুপ
| বাহু | হস্তক্ষেপ / চিকিত্সা |
|---|---|
| Experimental: GROUP A ( metformin 500 mg TDS) Life style modifications, Weight reduction and folic acid will be prescribed with metformin 500 mg three times a day | |
| Experimental: GROUP B( myoinositol 2000mg x BD ) Life style modifications, Weight reduction and folic acid will be prescribed with myoinositol 2000 mg two times a day | |
| Experimental: GROUP C.(both metformin,& myoinositol) Life style modifications, Weight reduction and folic acid will be prescribed with both metformin,& myoinositol three and two times a day respectively |
যোগ্যতার মানদণ্ড
| বয়স অধ্যয়নের জন্য যোগ্য | 16 Years প্রতি 16 Years |
| লিঙ্গ অধ্যয়নের জন্য যোগ্য | Female |
| স্বাস্থ্যকর স্বেচ্ছাসেবীদের গ্রহণ করে | হ্যাঁ |
| নির্ণায়ক | Inclusion Criteria: It will be based on the Rotterdam criteria of diagnosing PCO. Patients presenting with a history of secondary amenorrhea, irregular menstrual cycle, oligomenorrhea, weight gain, hirsutism, and already diagnosed cases of PCO will be included in this group. Exclusion Criteria: - Hyperprolactinemia - Cushing's disease - Hypothyroidism/ Hyperthyroidism - Pregnancy and nursing - Established type 1 or type 2 diabetes mellitus - Any history of drug intake e.g. anti-diabetic or estrogen and progesterone - History of treatment for the same complaint taken in the last 3 months - Unable to come for regular follow-ups - Any pathological cause of bleeding e.g. Fibroid, Polyp, Cervical pathology - Known allergic to these drugs |
ফলাফল
প্রাথমিক ফলাফল ব্যবস্থা
1. Menstrual cycle regulation [Follow up at 3rd and 6th months]
2. change in weight [Follow up at 3rd and 6th months]
মাধ্যমিক ফলাফলের ব্যবস্থা
1. Pregnancy / Miscarriage [1 year]
