Determination of Glycemic and Insulinemic Indices
কেবল নিবন্ধিত ব্যবহারকারীরা নিবন্ধগুলি অনুবাদ করতে পারবেন
প্রবেশ করুন - নিবন্ধন করুন
লিঙ্কটি ক্লিপবোর্ডে সংরক্ষিত হয়েছে
স্থিতি
স্পনসর
Finnish Institute for Health and Welfare
ক্লিনিকাল ট্রায়াল: NCT01477216
BioSeek: nct01477216
কীওয়ার্ডস
বিমূর্ত
The aim of this study to investigate methodological aspects that may affect glycemic index (GI) and insulinemic (II) values. In addition, we will measure GI and II values for typical Finnish carbohydrate-rich foods and provide a database of GIs for Finnish foods.
The specific aims of this study are:
- to compare glycemic responses and GIs analyzed from capillary and venous blood to compare glucose against white bread as the reference food, and to study the effect of number of reference tests on GI values. For each setting of the tested parameters, we determined the glycemic indices of rye bread, oatmeal porridge and instant mashed potato
- to examine the glycaemic and insulinaemic responses of a mashed potato-based meal when a high fat food (rapeseed oil) or a high protein food (chicken breast) or fat, protein and salad together were added to the meal. Furthermore, we studied how the predicted and measured GI values of the mixed meal differed from each other.
- to examine the effects of two different coffee portions with glucose and caffeine-containing soft drinks on postprandial glucose and insulin responses. Further objectives were to study how coffee and different accompaniments affect glucose and insulin responses.
- to measure GI values for typical Finnish foods
- to study the effects of berries on glycemic and insulinemic responses
- to examine the effects of overweight and glucose tolerance on the glucose, insulin and lipid responses to an HGI meal and an LGI meal.Furthermore, the second aim was to study the effect of BMI and glucose tolerance on the GI measured.
- to compare methodological choices in insulin measurement
- to investigate the effect of alcohol on postprandial glucose and insulin responses, and to determine glycemic and insulinemic indices values for beer and non-alcoholic beer
তারিখ
| সর্বশেষ যাচাই করা হয়েছে: | 10/31/2011 |
| প্রথম জমা দেওয়া: | 10/03/2011 |
| আনুমানিক তালিকাভুক্তি জমা দেওয়া হয়েছে: | 11/17/2011 |
| প্রথম পোস্ট: | 11/21/2011 |
| সর্বশেষ আপডেট জমা দেওয়া হয়েছে: | 11/17/2011 |
| সর্বশেষ আপডেট পোস্ট: | 11/21/2011 |
| আসল অধ্যয়ন শুরুর তারিখ: | 12/31/2002 |
| আনুমানিক প্রাথমিক সমাপ্তির তারিখ: | 11/30/2008 |
| আনুমানিক অধ্যয়ন সমাপ্তির তারিখ: | 11/30/2013 |
অবস্থা বা রোগ
Glucose Metabolism
হস্তক্ষেপ / চিকিত্সা
Other: ELSA 1-9
পর্যায়
-
বাহু গ্রুপ
| বাহু | হস্তক্ষেপ / চিকিত্সা |
|---|---|
| Experimental: Measuring method To compare glycemic responses and GI values from capillary and venous blood and to compare glucose solution with white bread as the reference food and to study the effect of the number of reference tests on GI values. | |
| Experimental: Mixed meals To examine the glycaemic and insulinaemic responses of a mashed potato-based meal when a high fat food (rapeseed oil) or a high protein food (chicken breast) or fat, protein and salad together were added to the meal. Furthermore, we studied how the predicted and measured GI values of the mixed meal differed from each other. | |
| Experimental: Coffee To examine the effects of two different coffee portions with glucose and caffeine-containing soft drinks on postprandial glucose and insulin responses. Further objectives were to study how coffee and different accompaniments affect glucose and insulin responses. | |
| Experimental: Snacks To measure GI and II values for Finnish snack foods | |
| Experimental: Berries To study the effects of berries on glycemic and insulinemic responses | |
| Experimental: GIs of low-carbs To measure glycemic and insulinemic responses to low-carbohydrates foods | |
| Experimental: Glucose metabolism and BMI To examine the effects of overweight and glucose tolerance on the glucose, insulin and lipid responses to an HGI meal and an LGI meal. Furthermore, the second aim was to study the effect of BMI and glucose tolerance on the GI measured. | |
| Experimental: Insulin measurement To compare how methodological choices affect measured insulin values | |
| Experimental: Alcohol To investigate the effect of alcohol on postprandial glucose and insulin responses, and to determine glycemic and insulinemic indices values for beer and non-alcoholic beer. |
যোগ্যতার মানদণ্ড
| বয়স অধ্যয়নের জন্য যোগ্য | 20 Years প্রতি 20 Years |
| লিঙ্গ অধ্যয়নের জন্য যোগ্য | All |
| স্বাস্থ্যকর স্বেচ্ছাসেবীদের গ্রহণ করে | হ্যাঁ |
| নির্ণায়ক | Inclusion Criteria: - For Studies 1-9 a total of 12 to 24 volunteers per study with a normal glucose tolerance based upon a 2 h 75g oral glucose tolerance test (OGTT). - For Study 7 a total of 24 volunteers with impaired glucose tolerance based on an OGTT. - For Studies 1-6 and 8-9 with an age of 20 to 60 and with a BMI of 18 to 30 kg/m2. - For Study 7 an age of 62 to 72 and with a BMI of 20 to 35 kg/m2. Exclusion Criteria: - First-degree family history of diabetes - An active gastrointestinal or metabolic disease - For Studies 1-6 and 8-9 chronic medication (oral contraceptives were allowed) - For Study 7 regular medication that would have affect glucose and lipid metabolism - Smoking - Pregnancy - Breastfeeding - History of polycystic ovary syndrome - History of gestational diabetes |
ফলাফল
প্রাথমিক ফলাফল ব্যবস্থা
1. Glucose [2 to 5 hours]
Area under the plasma concentration versus time curve (AUC) of food
2. Insulin [2 to 5 hours]
Area under the plasma concentration versus time curve (AUC) of food
3. Free fatty acids [2 to 5 hours]
Area under the plasma concentration versus time curve (AUC) of food
4. Triglyserides [2 to 5 hours]
Area under the plasma concentration versus time curve (AUC) of food
মাধ্যমিক ফলাফলের ব্যবস্থা
1. IGF1 [2 to 5 hours]
Area under the plasma concentration versus time curve (AUC) of food
2. Satiety [2 to 5 hours]
Satiety scores on the satiety scale
3. IGF-BP1 [2 to 5 hours]
Area under the plasma concentration versus time curve (AUC) of food
