Hypertonic Saline 75% vs Mannitol 20%
কীওয়ার্ডস
বিমূর্ত
বর্ণনা
Raised intracranial pressure occurs following an expansion of an intracranial mass e.g. hematoma or brain tumor and if left untreated, can lead to brain ischemia, stroke and death.
Strategies for reducing raised intracranial pressure include hyperventilation, use of a hyperosmolar agent and the evacuation of the intracranial mass.
The two hypertonic solutions most commonly used are Mannitol 20% and Hypertonic Saline 7.5%.
During elective neurosurgical removal of a brain tumour, the anesthesiologist needs to reduce intracranial pressure and provide good operating brain conditions to avoid brain ischemia.
Currently, Mannitol 20% is routinely used intra-operatively in these patients to reduce brain bulk and intracranial pressure and to improve brain operating conditions.
However, Mannitol itself can cause secondary effects that can be deleterious to the neurological patient. Mannitol causes a diuresis which may lead to systemic hypovolemia and hypotension, and adverse changes in serum and urinary sodium, potassium and osmolarity.
Experience with Hypertonic saline 7.5%, has been mainly in brain injured patients either in the Emergency Dept or in the Intensive care setting. There is growing evidence that Hypertonic saline 7.5% is just as effective as Mannitol 20% in reducing raised intracranial pressure, especially in traumatic brain injury and it has become a widely accepted form of treatment. One of the advantages of Hypertonic saline is that it does not cause a diuresis and therefore less likely to cause hypotension and hypovolemia. While transient hypernatremia has been observed after the administration of hypertonic saline, there have been no clinical consequences.
Unfortunately there have been only two studies which compared the effectiveness of Hypertonic saline and Mannitol during elective brain surgery. One of them, Gemma et al, failed to demonstrate any difference in the reduction of brain bulk between Mannitol and Hypertonic saline. However the 2 solutions used had different osmolarities and this may have had a confounding effect on the results. In the other study (published in Polish), the authors found a 20% reduction in brain bulk in favour of hypertonic saline. In view of these two opposing findings, we feel that another investigation is warranted.
তারিখ
সর্বশেষ যাচাই করা হয়েছে: | 10/31/2018 |
প্রথম জমা দেওয়া: | 09/12/2005 |
আনুমানিক তালিকাভুক্তি জমা দেওয়া হয়েছে: | 09/12/2005 |
প্রথম পোস্ট: | 09/19/2005 |
সর্বশেষ আপডেট জমা দেওয়া হয়েছে: | 11/01/2018 |
সর্বশেষ আপডেট পোস্ট: | 11/05/2018 |
আসল অধ্যয়ন শুরুর তারিখ: | 12/31/2004 |
আনুমানিক অধ্যয়ন সমাপ্তির তারিখ: | 03/31/2007 |
অবস্থা বা রোগ
হস্তক্ষেপ / চিকিত্সা
Drug: Administration of Hypertonic Solution 7.5% vs Mannitol 20%
পর্যায়
যোগ্যতার মানদণ্ড
বয়স অধ্যয়নের জন্য যোগ্য | 18 Years প্রতি 18 Years |
লিঙ্গ অধ্যয়নের জন্য যোগ্য | All |
স্বাস্থ্যকর স্বেচ্ছাসেবীদের গ্রহণ করে | হ্যাঁ |
নির্ণায়ক | Inclusion Criteria: - ASA physical status I - 3. - Age >18 years. - Scheduled for elective craniotomies for supratentorial brain tumour resection. - Written informed consent. Exclusion Criteria: - Within the past six months, a history of unstable angina pectoris and/or having a myocardial infarction. - Electrocardiogram abnormalities indicating severe ischemia. - Congestive heart failure. - Glasgow coma sore < 9 - Refusal to participate or refusal to agree to randomization. - Known renal failure - Known poorly controlled diabetes. |
ফলাফল
প্রাথমিক ফলাফল ব্যবস্থা
1. Surgeon's assessment of brain bulk. [undefined]
2. ICP reduction [undefined]
মাধ্যমিক ফলাফলের ব্যবস্থা
1. Changes in intracranial pressure [undefined]
2. Changes in serum and urine levels of sodium, potassium and osmolarity. [undefined]