Norepinephrine and Phenylephrine, Which Better for Elderly?
কীওয়ার্ডস
বিমূর্ত
তারিখ
| সর্বশেষ যাচাই করা হয়েছে: | 06/30/2019 |
| প্রথম জমা দেওয়া: | 07/19/2019 |
| আনুমানিক তালিকাভুক্তি জমা দেওয়া হয়েছে: | 08/20/2019 |
| প্রথম পোস্ট: | 08/27/2019 |
| সর্বশেষ আপডেট জমা দেওয়া হয়েছে: | 10/05/2019 |
| সর্বশেষ আপডেট পোস্ট: | 10/07/2019 |
| আসল অধ্যয়ন শুরুর তারিখ: | 10/05/2019 |
| আনুমানিক প্রাথমিক সমাপ্তির তারিখ: | 12/29/2019 |
| আনুমানিক অধ্যয়ন সমাপ্তির তারিখ: | 01/29/2020 |
অবস্থা বা রোগ
হস্তক্ষেপ / চিকিত্সা
Drug: norepinephrine
Drug: phenylephrine
পর্যায়
বাহু গ্রুপ
| বাহু | হস্তক্ষেপ / চিকিত্সা |
|---|---|
| Experimental: norepinephrine Blood pressure is generally maintained at value not less than 80% of baseline during intraoperative period. If the blood pressure is within normal range and SVV is less than 9, patient will be given a continuous infusion of crystalloid solution. However, when blood pressure drops and SVV is greater than 13, a bolus of 200mL colloid will then be quickly administered. If the blood pressure doesn't recover back to normal range within 5 minutes after bolus, norepinephrine will be given through the central venous catheter. If SVV is between 9 and 13, a bolus of crystalloid at 8mL/kg/h will be administered | Drug: norepinephrine patient who was received the treatment of norepinephrine |
| Experimental: phenylephrine Blood pressure is generally maintained at value not less than 80% of baseline during intraoperative period. If the blood pressure is within normal range and SVV is less than 9, patient will be given a continuous infusion of crystalloid solution. However, when blood pressure drops and SVV is greater than 13, a bolus of 200mL colloid will then be quickly administered. If the blood pressure doesn't recover back to normal range within 5 minutes after bolus, phenylephrine will be given through the central venous catheter. If SVV is between 9 and 13, a bolus of crystalloid at 8mL/kg/h will be administered. | Drug: phenylephrine patient who was received the treatment of phenylephrine |
যোগ্যতার মানদণ্ড
| বয়স অধ্যয়নের জন্য যোগ্য | 60 Years প্রতি 60 Years |
| লিঙ্গ অধ্যয়নের জন্য যোগ্য | All |
| স্বাস্থ্যকর স্বেচ্ছাসেবীদের গ্রহণ করে | হ্যাঁ |
| নির্ণায়ক | Inclusion Criteria: - radical resection of colorectal or gastric cancers, - age over 65 years old, - surgical time longer than 2hours, - the American Society of Anesthesiologists(ASA) classification of II or III Exclusion Criteria: - history of severe cardiovascular diseases, - history of severe liver and kidney diseases, - evidence of arrhythmia on EKG, - use of positive end-expiratory pressure (PEEP) during mechanical ventilation; - conditions with relative contraindication for arterial catheterization |
ফলাফল
প্রাথমিক ফলাফল ব্যবস্থা
1. hemodynamics- (CO)cardiac output [change from patient enters the operating room to end of operation, assessed up to the whole operation]
2. Tissue perfusion and oxygenation-(DO2) Oxygen delivery; [change from beginning of operation to end of operation, assessed up to the whole operation]
3. Tissue perfusion and oxygenation-(VO2)Oxygen consumption; [change from beginning of operation to end of operation, assessed up to the whole operation]
