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A gastrinoma is a tumor derived from G cells in the duodenum, pancreas or less commonly stomach, that secretes the peptide hormone gastrin. There is hypersecretion of HCl acid into the duodenum, which causes the ulcers. Excessive HCl acid production also causes hyperperistalsis, and inhibits the activity of lipase, causing severe diarrhea.

It is frequently the source of the gastrin in Zollinger-Ellison syndrome.A gastrinoma in the pancreas has a greater potential for malignancy. Most gastrinomas ...