[Effect of phillyrin on the anti-obesity in nutritive obesity mice].

OBJECTIVE

To study on the anti-obesity effect of phillyrin in nutritive obesity mice.

METHODS

The alimentary obesity model was established by hyperalimentation. The wet weight of fat, fat index, number of fat cells per unit visual field, Lee's index, jejunum microvillus area, serum triglyceride and cholesterol were selected to observe the anti-obesity effect of phillyrin.

RESULTS

Phillyrin could lower wet weight of fat (P < 0.01), fat index (P < 0.05 or P < 0.01), diameter of fat cell and Lee's index (P < 0.05), decrease the jejunum microvillus area, lower the level of serum triglyceride and cholesterol.

CONCLUSIONS

Phillyrin has anti-obesity effect in nutritive obesity mice.