6 ফলাফল
BACKGROUND OF THE INVENTION
This invention relates to the use of adenosine 5'-diphosphate (ADP) and/or adenosine 5'-triphosphate (ATP) for selective inhibition of growth and subsequent killing of malignant cells, e.g., human malignant cells, thereby utilizing a normal metabolite for inhibiting,
CROSS-REFERENCE TO RELATED APPLICATION
This application is a continuation of International Application No. PCT/US03/01166 filed Jan. 16, 2003, the entire disclosure of which is incorporated herein by reference.
TECHNICAL FIELD
The present invention relates to methods and therapeutic compositions
FIELD OF THE INVENTION
The invention relates to pharmaceutical agents and methods for use in the treatment of cancer. More specifically, the invention relates to treatment of cancer cells with L-alanosine to inhibit de novo adenosine 5'-triphosphate (ATP) synthesis in such cancer cells. In
BACKGROUND OF THE INVENTION
The invention relates to pharmaceutical agents and methods for use in chemotherapeutic treatment of cancer. More specifically, the invention relates to the identification of cancer cells which cannot metabolize methylthioadenosine phosphorylase to adenine for the salvage
BACKGROUND OF THE INVENTION
The invention relates to pharmaceutical agents and methods for use in chemotherapeutic treatment of cancer. More specifically, the invention relates to the identification of cancer cells which cannot metabolize methylthioadenosine phosphorylase to adenine for the salvage
DESCRIPTION
1. Technical Field
The present invention is concerned with the selective inhibition of the growth and subsequent killing of tumor cells in a host (e.g., human tumor cells) by increasing the blood and plasma adenosine 5'- triphosphate (ATP) levels in the host. The elevated blood and