Pistachios, Performance, Metabolomics

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StatusZavršeno

Sponzori

Appalachian State University

Saradnici

American Pistachio Growers

KLINIČKIM ISPITIVANJIMA: NCT01821820

BioSeek: nct01821820

Ključne riječi

Sažetak

Ingestion of 3 ounces of pistachio nuts per day for two weeks before and the day of cycling intensely for 75 kilometers will support substrate utilization during exercise (as determined through metabolomics) and improve performance compared to water only, and attenuate inflammation, oxidative stress, and immune dysfunction during 24 hours of recovery.

Datumi

Posljednja provjera:	12/31/2014
Prvo podneseno:	03/26/2013
Predviđena prijava predata:	03/28/2013
Prvo objavljeno:	03/31/2013
Zadnje ažuriranje poslato:	01/29/2015
Posljednje ažuriranje objavljeno:	02/01/2015
Stvarni datum početka studija:	02/28/2013
Procijenjeni datum primarnog završetka:	05/31/2014
Predviđeni datum završetka studije:	06/30/2014

Stanje ili bolest

Inflammation

Oxidative Stress

Immune Dysfunction

Intervencija / liječenje

Other: Pistachios

Faza

Grupe ruku

Arm	Intervencija / liječenje
Experimental: Pistachios Pistachio treatment (3 oz/d) for two weeks; 3 oz pistachio nuts and water (1.5 oz. before, and 1.5 oz during) cycling 75 km.	Other: Pistachios
No Intervention: No pistachios No pistachios for two weeks, or before and during 75 km cycling.

Kriteriji prihvatljivosti

Uzrast podoban za studiranje	18 Years To 18 Years
Polovi podobni za studiranje	Male
Prihvaća zdrave volontere	Da
Kriterijumi	Inclusion Criteria: - Male endurance cyclists - Capable of exercising for 2.5 h at a high intensity in the lab - Ages 18-55 - Agree to train normally and stay weight stable. - Agree to avoid the use of large dose vitamin/mineral supplements - Agree to avoid herbs and medications that influence inflammation Exclusion Criteria: - Regularly take supplements or medicines known to effect inflammation. - At moderate or high risk for cardiovascular disease. - Younger than 18 or older than 55 years of age. - No history of competing in cycling races.

Ishod

Primarne mjere ishoda

1. Shifts in metabolites (metabolomics) [14-day period]

Shifts in metabolites pre-and post-14-days supplementation, and then after 75-km cycling, and the next morning.

Sekundarne mjere ishoda

1. Inflammation [14-day period]

Pre- and post-14 d supplementation, and following 75-km cycling; plasma IL-6, IL-8, IL-10, TNF-alpha, G-CSF, MCP-1; C-reactive protein

2. Immune Function [14-day period]

Pre- and post-14 days supplementation, and following 75-km cycling; granulocyte and monocyte phagocytosis and oxidative burst activity; leukoycte differential

3. Oxidative Stress [14-day period]

Pre- and post-14 days supplementation, and following 75-km cycling; RBC glutathione, protein carbonyls, ORAC, FRAP, F2-isoprostanes