Serum Magnesium Level Administration in Severe Pre-eclampsia Obese Pregnancy
Ključne riječi
Sažetak
Opis
Magnesium sulfate is, generally, applied in order to alleviate or to avoid seizures. It can be administered according to many medical approaches. Nevertheless, at Rajavithi Hospital, the recommended administration of magnesium sulfate is 4 grams for loading dose in 15 minutes, followed by 2 grams for maintenance dose per hour (Zudpan regimen). The therapeutic index of magnesium is in the range of 4.8-8.4 mg/dL. After that, the level of magnesium sulfate will be evaluated every 4 or 6 hours.
At Rajavithi Hospital, there are a lot of patients having pre-eclampsia symptom and many patients, who were received magnesium sulfate in the treatment, having the level of magnesium sulfate lower than the therapuetic level and needed to increase the maintenance dose to 2.5 grams/hour. Therefore, this work aims to studying the amount of magnesium sulfate administered to pregnant woman with pre-eclampsia symptom who possess high body mass index (BMI), especially for BMI greater than or equal to 30 kg/m2.
Datumi
| Posljednja provjera: | 08/31/2018 |
| Prvo podneseno: | 05/13/2018 |
| Predviđena prijava predata: | 09/04/2018 |
| Prvo objavljeno: | 09/06/2018 |
| Zadnje ažuriranje poslato: | 09/04/2018 |
| Posljednje ažuriranje objavljeno: | 09/06/2018 |
| Stvarni datum početka studija: | 09/29/2018 |
| Procijenjeni datum primarnog završetka: | 12/29/2018 |
| Predviđeni datum završetka studije: | 12/29/2018 |
Stanje ili bolest
Intervencija / liječenje
Drug: Magnesium sulfate administration
Faza
Grupe ruku
| Arm | Intervencija / liječenje |
|---|---|
| Experimental: controlled group controlled group : administration of magnesium sulfate is 4 grams for loading dose in 15 minutes, followed by 2 grams for maintenance dose per hour | |
| Experimental: Experimental group group : administration of magnesium sulfate is 4 grams for loading dose in 15 minutes, followed by 2.5 grams for maintenance dose per hour |
Kriteriji prihvatljivosti
| Polovi podobni za studiranje | Female |
| Prihvaća zdrave volontere | Da |
| Kriterijumi | Inclusion Criteria: - Pregnancy women who have MBI ≥ 31kg/m2 - Pregnancy women who were diagnosed severe pre-eclampsia at gestational age 24 weeks more. - Pregnancy women who were diagnosed eclampsia at gestational age 24 weeks more. Exclusion Criteria: - Pregnancy women who were chronic kidney disease or have serum creatinine more than 1.1 mg/dl - Pregnancy women who have contraindication to use magnesium sulfate |
Ishod
Primarne mjere ishoda
1. therapeutic level [4 hours after infusion magnesium sulfate]
Sekundarne mjere ishoda
1. Outcome of pregnancy [24 hours after delivery]
