Cardiovascular and respiratory effects of antiarrhythmic drugs on conscious beagles.
Ključne riječi
Sažetak
Cardiovascular effects of antiarrhythmic drugs and their effects on the respiratory rate were examined in conscious beagles. Disopyramide, 1.5 mg/kg i.v., increased the blood pressure and decreased the heart rate, but higher dose of 5 mg/kg i.v. increased both. Disopyramide showed no central nervous side effects. Procainamide, 20 and 60 mg/kg i.v., increased the blood pressure and heart rate without changing the respiratory rate. A higher dose (60 mg/kg i.v.) of procainamide induced vomiting. Lidocaine, 2 and 6 mg/kg i.v., and phenytoin, 3 and 10 mg/kg i.v., simultaneously increased the blood pressure, heart rate and respiratory rate accompanied by excitement, and with a higher dose (6 mg/kg i.v.) of lidocaine, by convulsions. Verapamil, 0.1 and 0.3 mg/kg i.v., induced tachycardia without serious neurological effects. In conscious healthy dogs cardiovascular depressant actions of antiarrhythmic drugs could only rarely be observed.