Hypericum perforatum and substance dependence: a review.

Substance abuse and dependence is a serious problem throughout the world. The development of several types of dependence remedies has medical, social and economical significance. In particular, alcohol and tobacco are the most commonly abused substances worldwide. An extract of Hypericum perforatum L. (HPE) displayed a clear antidepressant action and it has been used for the treatment of mild to moderate depression. Recent reports imply that HPE may be effective in the treatment of substance abuse. Studies have focused on alcohol and nicotine dependence. In this review, the effects of HPE on substance dependence and its possible benefit have been discussed in the light of current literature.