[Role of non antiarrhythmic medications in the prevention of atrial fribrillation].

After cardioversion of atrial fibrillation, structural and electrophysiologic remodelling of the atria is implicated in the arrhythmia recurrences despite antiarrhythmic drug treatment. Strategies targeting this substrate have therefore been proposed. In this view, Renin angiotensin system inhibition and drugs targeting inflammation and oxidative injury are the most promising strategies up to now. We discuss here the rationale and evidence which are behind these therapeutic approaches.