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3 4 dihydroxyphenylacetic acid/karijes

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Pharmacological evidence for feedback regulation of dopamine metabolism in solid fetal substantia nigra transplants.

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Solid grafts of fetal ventral mesencephalic tissue transplanted into a cavity overlying a dopamine (DA)-deafferented striatum are known to survive, send terminals into the host striatum and release DA. Using this preparation, we have examined receptor-mediated feedback modulation of DA metabolism in

Chronic inhalation of rotenone or paraquat does not induce Parkinson's disease symptoms in mice or rats.

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Epidemiological studies suggest that some pesticides might constitute a risk factor for Parkinson's disease (PD). However, risk assessment cannot be performed in the current experimental animal models because they use non-natural pathways of pesticide exposure, such as intraperitoneal or intravenous
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